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Effects of histamine on gastric blood flow

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The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

In anesthetized dogs, volume flow rate of blood to the stomach and distribution of blood through the stomach were studied by means of an electromagnetic flow meter and a surface counting technic. Simultaneous measurements of gastric secretory activities were made. Histamine was found to decrease volume flow rate of blood to the stomach. Distribution of blood through the stomach was altered by histamine. Whereas under resting conditions distribution of blood flow was predominantly antral, during histamine-induced gastric hypersecretion, blood flow tended to shift toward the fundus and away from the antrum. Therefore, it appears that distribution of blood through the stomach is not uniform but is characterized by a “borrowing and lending” phenomenon.

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References

  1. Cutting, W. C., Dodds, E. C., Noble, R. L., andWilliams, P. C. Pituitary control of alimentary blood flow and secretion. The effect of alteration in blood flow on gastric secretion.Proc. Roy. Soc. London 123:39, 1937.

    Google Scholar 

  2. Walder, D. N. Arteriovenous anastomoses of the human stomach.Clin. Sc. 11:59, 1952.

    Google Scholar 

  3. Peters, R. M., andWomack, N. A. Hemodynamics of gastric secretion.Ann. Surg. 148:537, 1958.

    PubMed  Google Scholar 

  4. Sevelius, G., andJohnson, P. C. Coronary blood flow determined by surface counting and ratio formula.J. Lab.& Clin. Med. 54:669, 1959.

    Google Scholar 

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Authors and Affiliations

  1. From the Department of Surgery, University of Oklahoma Medical Center and Veterans Administration Hospital, Oklahoma City, Okla.

    Rene Menguy M.D., Ph.D.

  2. University of Kentucky Medical Center, Lexington, Ky.

    Rene Menguy M.D., Ph.D.

Authors
  1. Rene Menguy M.D., Ph.D.
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Additional information

The work described in this article was supported in part by Grant A3934 from the National Institutes of Health and Grant E-186 from the American Cancer Society.

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Menguy, R. Effects of histamine on gastric blood flow. Digest Dis Sci 7, 383–393 (1962). https://doi.org/10.1007/BF02232358

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  • DOI: https://doi.org/10.1007/BF02232358

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