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Bile salt and lipid metabolism in patients with ileal disease with and without steatorrhea

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Abstract

Postcibal duodenal contents and the enterohepatic circulation of intravenously administered sodium taurocholate-24-14C were studied in 8 patients with ileal disease and the data compared with that of a control group. Seven patients had an interrupted enterohepatic circulation of taurocholate; all had a normal fasting cholate pool size. Studies on the postcibal duodenal contents showed that 7 patients had concentrations of cholate and aqueous phase lipid comparable to controls during the first 30 minutes after feeding, whereas these values were comparably reduced during the subsequent 90 minutes. Four patients required special considerations. One patient with steatorrhea had an unstimulated release of bile salts into his duodenum, with resultant low cholate and aqueous phase lipid values during the entire postcibal study. One patient with Crohn's disease was physiologically normal. Two patients had no steatorrhea despite an interrupted enterohepatic taurocholate circulation. These results point up the value of correlative studies and suggest that certain patients may successfully compensate, as regards lipid absorption, for an interrupted enterohepatic circulation of bile salts.

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Authors and Affiliations

  1. From the Veterans Administration Hospital, Durham

    Charles M. Mansbach II MD, John T. Garbutt Jr MD & Malcolm P. Tyor MD

  2. NC and the Department of Medicine, Duke University Medical Center, Durham, NC

    Charles M. Mansbach II MD, John T. Garbutt Jr MD & Malcolm P. Tyor MD

Authors
  1. Charles M. Mansbach II MD
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  2. John T. Garbutt Jr MD
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  3. Malcolm P. Tyor MD
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Additional information

This work was supported by the Veterans Administration Hospital, Durham, NC and by Research Grant AM-8500 and Training Grant TI AM-5093, US Public Health Service. The services of the Clinical Research Unit were supported by Grant MO-1-FR 30 from the National Institutes of Health.

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Mansbach, C.M., Garbutt, J.T. & Tyor, M.P. Bile salt and lipid metabolism in patients with ileal disease with and without steatorrhea. Digest Dis Sci 17, 1089–1099 (1972). https://doi.org/10.1007/BF02232311

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