The American Journal of Digestive Diseases

, Volume 9, Issue 4, pp 256–262 | Cite as

The effect of extragastric vagotomy on Heidenhain-pouch secretion in dogs

  • John H. Landor


Three of 4 dogs with antrectomy and Heidenhain pouches exhibited an increase in pouch secretion after extragastric vagotomy. Further increases in secretion were observed following transthoracic vagotomy. The elevation in gastric secretion induced by extragastric vagotomy is believed to result from changes in biliary, pancreatic, and/or intestinal function secondary to parasympathetic denervation. The additional increases in pouch secretion after transthoracic (gastric) vagotomy were most likely related to the lowered production of acid by the stomach.


Public Health Lowered Production Gastric Secretion Additional Increase Intestinal Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dragstedt, L. R., II, Johnson, A. N., Jr., Singer, E. R., andOberhelman, H. A., Jr. The effect of vagotomy on the intestinal phase of gastric secretion.Surg. Forum 11:336, 1960.PubMedGoogle Scholar
  2. 2.
    Schmitz, E. J., Kanar, E. A., Storer, E. H., Sauvage, L. R., andHarkins, H. N. The effect of vagotomy of the main stomach on Heidenhain pouch secretion.Surg. Forum 3:17, 1953.Google Scholar
  3. 3.
    Evans, S. O., Jr., Zubiran, J. M., McCarthy, J. D., Ragins, H., Woodward, E. R., andDragstedt, L. R. Stimulating effect of vagotomy on gastric secretion in Heidenhain pouch dogs.Am. J. Physiol. 174:219, 1953.PubMedGoogle Scholar
  4. 4.
    Griffith, C. A. Gastric vagotomy vs. total abdominal vagotomy.A.M.A. Arch. Surg. 81:781, 1960.Google Scholar
  5. 5.
    Burge, H. W., Rizk, A. R., Tompkin, A. M. B., Barth, C. E., Hutchison, J. S. F., Longland, C. J., McLennan, I., andMiln, D. C. Selective vagotomy in the prevention of post-vagotomy diarrhoea.Lancet 2:897, 1961.PubMedGoogle Scholar
  6. 6.
    Kraft, R. O., Fry, W. J., andRansom, H. K. Selective gastric vagotomy.Arch. Surg. 85:687, 1962.PubMedGoogle Scholar
  7. 7.
    Smith, G. K., andFarris, J. M. Some observations upon selective gastric vagotomy.Arch. Surg. 86: 716, 1963.PubMedGoogle Scholar
  8. 8.
    Harkins, H. N., Stavney, L. S., Griffith, C. A., Savage, L. E., Kato, T., andNyhus, L. M. Selective gastric vagotomy.Ann. Surg. 158:448, 1963.PubMedGoogle Scholar
  9. 9.
    Jackson, R. G. An anatomic study of the vagus nerves and a technique of trans-abdominal gastric vagus resection.Univ. Mich. Med. Bull. 13:31, 1947.Google Scholar
  10. 10.
    Jackson, R. G. Anatomic study of the vagus nerves, with a technique of trans-abdominal selective gastric vagus section.A.M.A. Arch. Surg. 57:333, 1948.Google Scholar
  11. 11.
    Franksson, C. Selective abdominal vagotomy.Acta chir. scandinav. 96:409, 1948.Google Scholar
  12. 12.
    Jefferson, N. C, andNecheles, H. The effect of phrenicotomy on gastrointestinal mechanisms.Proc. Soc. Exper. Biol. & Med. 68:166, 1948.Google Scholar
  13. 13.
    Kelly, K. A., Nyhus, L. M., andHarkins, H. N. Vagal effects on the intestinal phase of gastric secretion. (Abst.).Gastroenterology 44:862, 1963.Google Scholar
  14. 14.
    Snape, W. J. Studies on the gall-bladder in unanesthetized dogs before and after vagotomy.Gastroenterology 10:129, 1948.Google Scholar
  15. 15.
    Stavney, L. S., Kato, T., Griffith, C. A., Nyhus, L. M., andHarkins, H. N. A physiologic study of motility changes following selective gastric vagotomy.J. Surg. Res. 3: 390, 1963.Google Scholar
  16. 16.
    Johnson, F. E., andBoyden, E. A. The effect of double vagotomy on the motor activity of the human gallbladder.Surgery 32:591, 1952.PubMedGoogle Scholar
  17. 17.
    Cox, H. T., Doherty, J. F., andKerr, D. R. Changes in the gallbladder after elective gastric surgery.Lancet 1:764, 1958.PubMedGoogle Scholar
  18. 18.
    Harper, A. A., Kidd, C, andScratcherd, T. Vago-vagal reflex effects on gastric and pancreatic secretion and gastrointestinal motility.J. Physiol. (London)148: 417, 1959.PubMedGoogle Scholar
  19. 19.
    Pincus, I. J., Thomas, J. E., andLachman, P. O. The effect of vagotomy on the secretion of pancreatic juice after ingestion of various foodstuffs.Fed. Proc. 7:94, 1948.Google Scholar
  20. 20.
    Hayama, T., Magee, D. F., andWhite, T. T. Influence of autonomic nerves on the daily secretion of pancreatic juice in dogs.Ann. Surg. 158:290, 1963.PubMedGoogle Scholar
  21. 21.
    Routley, E. F., Mann, F. C., Bollman, J. L., andGrindlay, J. H. Effects of vagotomy on pancreatic secretion in dogs with chronic pancreatic fistula.Surg. Gynec. & Obst. 95:529, 1952.Google Scholar
  22. 22.
    Pfeffer, R. B., Stephenson, H. E., Jr., andHinton, J. W. The effect of thoracolumbar sympathectomy and vagus resection on pancreatic function in man.Ann. Surg. 136:585, 1952.PubMedGoogle Scholar
  23. 23.
    White, T. T., Lundh, G., andMagee, D. F. Evidence for the existence of a gastropancreatic reflex.Am. J. Physiol. 198:725, 1960.PubMedGoogle Scholar
  24. 24.
    Wthite, T. T., McAlexander, R. A., andMagee, D. F. Gastropancreatic reflex after various gastric operations.Surg. Forum 13:286, 1962.PubMedGoogle Scholar
  25. 25.
    Beal, J. M., andDineen, P. A study of vagotomy.A. M. A. Arch. Surg. 60:203, 1950.Google Scholar
  26. 26.
    Isaac, F., Ottoman, R. E., andWeinberg, J. A. Roentgen studies of the upper gastrointestinal tract in vagotomy.Am. J. Roentgenol. 63:66, 1950.Google Scholar
  27. 27.
    Fox, H. J., andGrimson, K. S. Defective fat absorption following vagotomy.J. Lab. Clin. Med. 35: 362, 1950.Google Scholar
  28. 28.
    Ballinger, W. F., II. The small intestine following vagotomy.Surg. Gynec. & Obst. 116:115, 1963.Google Scholar
  29. 29.
    Tucker, F. H., Jr., Barnett, W. O., andGoodrich, J. K. Influence of various degrees of vagotomy upon fat, carbohydrate and protein absorption following pyloroplasty.Surg. Forum 14:364, 1963.PubMedGoogle Scholar
  30. 30.
    Ballinger, W. F., II, Christy, M. G., andAshby, W. B. Autotransplantation of the small intestine: the effect of denervation.Surgery 52:151, 1962.PubMedGoogle Scholar
  31. 31.
    Ballinger, W. F., II, Iida, J., andAponte, G. E. Changes in the small intestine following total and selective vagotomy.Surg. Forum 14:366, 1963.PubMedGoogle Scholar
  32. 32.
    Ballinger, W. F., II, Iida, J., Aponte, G. E., Wirts, C. W., andGoldstein, F. Structure and function of the canine small intestine following total abdominal vagotomy. In press.Google Scholar
  33. 33.
    Ballinger, W. F., II. Personal communication.Google Scholar
  34. 34.
    Menguy, R. Effect of biliary diversion from the small intestine on gastric secretory activity in dogs.Gastroenterology 41:568, 1961.PubMedGoogle Scholar
  35. 35.
    Goelzer, R. E. The effects of total pancreatectomy on gastric secretion.Surg. Forum 10:167, 1959.Google Scholar
  36. 36.
    Greenlee, H. B., Nelsen, T. S., andDragstedt, L. R. Studies on the relation of the pancreas to gastric secretion.Surg. Forum 10:161, 1959.Google Scholar
  37. 37.
    Elliott, D. W., Taft, D. A., Passaro, E., Jr., andZollinger, R. M. Pancreatic influences on gastric secretions.Surgery 50:126, 1961.PubMedGoogle Scholar
  38. 38.
    Greenlee, H. B., Johnson, A. N., Jr., Nelsen, T. S., andDragstedt, L. R. Total pancreatic duct ligation. Effect on gastric secretion.A. M. A. Arch. Surg. 83:872, 1961.Google Scholar
  39. 39.
    Skillman, J. J., Silen, W., Harper, H. A., Neely, J. C, andSimmons, E. L. Effect of hepatocellular injury on gastric secretion in dogs.Surg. Forum 12:276, 1961.PubMedGoogle Scholar
  40. 40.
    Silen, W., Hein, M. F., Albo, R. J., andHarper, H. A. Influence of liver upon canine gastric secretion.Surgery 54:29, 1963.PubMedGoogle Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1964

Authors and Affiliations

  • John H. Landor
    • 1
  1. 1.From the Department of SurgeryUniversity of Missouri School of MedicineColumbia

Personalised recommendations