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Effects of regitine and reserpine on portal hypertension

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Summary

1. Effects on portal pressure of 5 mg. of Regitine or 2.5 mg. of reserpine given intramuscularly were studied in 18 cirrhotic patients and 2 normal individuals.

2. Hepatic venous pressure was measured with a wedged catheter in 13 patients with cirrhotic livers and 2 patients with normal livers. Intra-splenic pressure by splenic puncture was determined in 2 other patients with cirrhosis.

3. In 10 cirrhotic patients, Regitine reduced the hepatic vein wedged pressure. This effect was transient lasting 2–5 min., after which it tended to return to control values. During these measurements, no systemic effect on arterial pressure was detected in 5 patients; however, in 4 patients, cardiac output failed to show significant differences after Regitine. One hour after injection of reserpine there was a reduction on the hepatic vein wedged pressure in 3 patients.

4. Intrasplenic pressure was measured in 2 patients. A reduction of this pressure was recorded in 1 patient 24 hr. after injection.

5. The significance of these changes and their possible causes are discussed.

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Authors and Affiliations

  1. From the Department of Medicine, Division of Nuclear Medicine, Catholic University of Santiago, Chile

    Ismael G. Mena M.D., Héctor M. Orrego M.D., Enrique Baraona M.D. & Silvio Marques M.D. (Fellow of the OEA)

  2. the Gastroenterology Center, Department of Internal Medicine, J. J. Aguirre Hospital, University of Chile, Santiago, Chile

    Ismael G. Mena M.D., Héctor M. Orrego M.D., Enrique Baraona M.D. & Silvio Marques M.D. (Fellow of the OEA)

  3. Bahia, Brazil

    Silvio Marques M.D. (Fellow of the OEA)

Authors
  1. Ismael G. Mena M.D.
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  2. Héctor M. Orrego M.D.
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  3. Enrique Baraona M.D.
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  4. Silvio Marques M.D.
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Additional information

This work was done with the assistance of the Rockefeller Foundation.

The authors wish to express their appreciation to the Center of Cardiology, Joaquin Aguirre Hospital, for assistance in hepatic vein catheterization and to Dr. W. Peters, M.B., Research Department, CIBA Laboratories, Basle, Switzerland, for supplying Regitine.

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Mena, I.G., Orrego, H.M., Baraona, E. et al. Effects of regitine and reserpine on portal hypertension. Digest Dis Sci 8, 895–903 (1963). https://doi.org/10.1007/BF02232084

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  • DOI: https://doi.org/10.1007/BF02232084

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