The American Journal of Digestive Diseases

, Volume 8, Issue 6, pp 537–544 | Cite as

Association of ulcerative colitis and red blood cells coated with autoimmune antibody

Report of a case
  • J. A. Balint
  • W. J. Hammack
  • T. B. Patton
Case Reports


A young woman with chronic ulcerative colitis, rheumatic heart disease, and mild diabetes mellitus, and who had not had any blood transfusions, developed an autoimmune antibody directed against her own erythrocytes with positive-direct and negative-indirect Coombs' tests. The antibodies disappeared after total colectomy, but were not affected by partial removal of the colon. No circulating anticolon antibodies could be demonstrated in the patient's serum, nor were antinuclear antibodies detected by L.E. cell preparations, nucleoprotein-coated latex particles, or by fluorescent antibody technics. Since the antibodies coating the red cells were specific for the molecular structure of the antigens e and f, it is suggested that they developed following absorption of damaged red cells through the ulcerated colonic mucosa and that antibody production stopped when this process was abolished by total colectomy.


Ulcerative Colitis Colonic Mucosa Antinuclear Antibody Latex Particle Cell Preparation 
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Copyright information

© Hoeber Medical Division of Harpir & Row, Publishers 1963

Authors and Affiliations

  • J. A. Balint
    • 1
    • 2
  • W. J. Hammack
    • 1
    • 2
  • T. B. Patton
    • 1
    • 2
  1. 1.From the Division of Gastroenterology and the Division of Hematology, Department of Medicine and Department of SurgeryUniversity of Alabama Medical Center, and the Veterans Administration HospitalBirmingham
  2. 2.Department of MedicineAlbany Medical CollegeAlbany

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