Association of ulcerative colitis and red blood cells coated with autoimmune antibody
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A young woman with chronic ulcerative colitis, rheumatic heart disease, and mild diabetes mellitus, and who had not had any blood transfusions, developed an autoimmune antibody directed against her own erythrocytes with positive-direct and negative-indirect Coombs' tests. The antibodies disappeared after total colectomy, but were not affected by partial removal of the colon. No circulating anticolon antibodies could be demonstrated in the patient's serum, nor were antinuclear antibodies detected by L.E. cell preparations, nucleoprotein-coated latex particles, or by fluorescent antibody technics. Since the antibodies coating the red cells were specific for the molecular structure of the antigens e and f, it is suggested that they developed following absorption of damaged red cells through the ulcerated colonic mucosa and that antibody production stopped when this process was abolished by total colectomy.
KeywordsUlcerative Colitis Colonic Mucosa Antinuclear Antibody Latex Particle Cell Preparation
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- 2.Perlman, P., andBroberger, O. Auto-antibodies against antigen derived from colon in the microsomes of regional colonic lymph glands in human ulcerative colitis.Nature, London 188:749, 1960.Google Scholar
- 3.Thayer, W., Spiro, H. M., andCalabresi, P. Antinuclear globulins in ulcerative colitis.Clin. Res. 8:369, 1960.Google Scholar
- 4.Asherton, G. L., andBroberger, O. Incidence of haemagglutinating and complement-fixing antibodies.Brit. M. J. 1:1429, 1961.Google Scholar
- 5.Calabresi, P., Thayer, W. R., Jr., andSpiro, H. M. Demonstration of circulating antinuclear globulins in ulcerative colitis.J. Clin. Invest. 40:2126, 1961.Google Scholar
- 8.Westphal, O., Luderitz, O., andBister, F. Uber die extraction von bakterien mit phenol/wasser.Ztschr. Naturforsch. 7b b:148, 1952.Google Scholar