Immune mechanisms in chronic pancreatic disease
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The presence of precipitins to pancreatic antigens was investigated by gel diffusion in two experimental conditions in dogs: pancreatic-duct ligation, and ethionine-induced pancreatitis. Precipitins to the pancreas were not demonstrable after pancreatic-duct ligation, but were demonstrable in other dogs, after small doses of ethionine had been administered for a short time, and in the absence of clinical or other laboratory evidence of pancreatic damage.
Histologic study of the pancreases of dogs that were sacrificed after ethionine administration showed disruption of acini and focal inflammation. The pancreas from a dog that was kept alive for 10 weeks following ethionine administration was found to be histologically normal-even though circulating precipitins to its own pancreas had been demonstrated in this animal.
The administration of dog-pancreas antisera to normal dogs did not produce any appreciable damage to their pancreases.
Our data suggest that, in dogs, certain forms of pancreatic damage may result in the production of circulating precipitating antibodies. Their significance in the production or perpetuation of pancreatic disease is unknown, but it is possible that they have no pathogenetic significance.
KeywordsPublic Health Pancreatitis Small Dose Histologic Study Immune Mechanism
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