Hemostasis in a case of tropical sprue with bleeding diathesis
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1. A bleeding tendency in tropical sprue is rare, in contrast to the frequent occurrence of bleeding in other malabsorption syndromes.
2. Bleeding phenomena were seen in only 1 of 36 patients with tropical sprue in this study. A report of a case of bleeding diathesis is given.
3. Tests of hemostasis in patients with tropical sprue indicate frequent thrombocytopenia. Prolonged one-stage prothrombin time is also common.
4. The prolonged prothrombin times appear to be due chiefly to a deficiency of stable factor. This deficiency in turn is most likely the result K avitaminosis.
KeywordsPublic Health Thrombocytopenia Prothrombin Prothrombin Time Frequent Occurrence
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- 1.Suarez, R. M. Clinical and hematological review of sprue based on the study of 150 cases.Ann. Int. Med. 12:529, 1938.Google Scholar
- 2.Diaz-Rivera, R. S. Prothrombin time in tropical sprue.Puerto Rico J. Pub. Health 17:124, 1941.Google Scholar
- 3.Rodriguez-Molina, R. Fundamental concepts in the diagnosis of sprue.Ann. Int. Med. 40:33, 1953.Google Scholar
- 4.Stefanini, M. Clinical features and pathogenesis of tropical sprue.Medicine 27: 379, 1948.Google Scholar
- 5.Castle, W. B., Rhoads, C. P., Lawson, H. A., andPayne, G. C. Etiology and treatment of sprue: Observation on patients in Puerto Rico and subsequent experiments in animals.A. M. A. Arch. Int. Med. 56:627, 1935.Google Scholar
- 6.Clark, R. L. Jr., Dixon, L. F., Butt, H. R., andShell, A. M. Deficiency of prothrombin associated with various intestinal disorders; its treatment with the antihemorrhagic vitamin (vitamin K).Proc. Staff Meet. Mayo Clin. 14: 407, 1939.Google Scholar
- 7.Kark, R. M., Souter, A. W., andHayward, J. C. Hemorrhagic diathesis in idiopathic steatorrhea.Quart. J. Med. 9:247, 1940.Google Scholar
- 8.Alper, J. M. The hemorrhagic tendency in sprue.Rev. Gastroenterol. 9: 340, 1942.Google Scholar
- 9.Collins, E. N., andHoffman, A. D. Hemoptysis and hematuria in sprue.Importance of vitamin K metabolism. Cleveland Clin. Quart. 10:105, 1943.Google Scholar
- 10.Adlersberg, D., andSchein, J. Clinical and pathological studies in sprue.J.A.M.A. 134: 1459, 1947.Google Scholar
- 11.Bjerkelund, C. J. Symptomatic sprue.. Acta med. scandinav. 137:130, 1950.Google Scholar
- 13.Moore, M. J., Strickland, W. H., andPrichard, R. W. Sprue with bleeding from hypoprothrombinemia.A.M.A. Arch. Int. Med. 97:814, 1956.Google Scholar
- 14.Wang, C. I., andBossak, E. T. Hemorrhagic manifestations in idiopathic sprue: A report on 25 cases and a review of the literature. InMalabsorption Syndrome, ed by D. Adlersberg, New York, Grune 1957, p. 143.Google Scholar
- 15.Diaz-Rivera, R. S., Suarez, R. M., andHernandez-Morales, F. Hypoprothrombinemia incident to tropical and non-tropical diseases.Bol. Asoc. Med. Puerto Rico 34: 177, 1942.Google Scholar
- 16.Butt, H. R., Snell, A. M., andOsterberg, A. E. Preoperative and postoperative administration of vitamin K to patients having jaundice.J.A.M.A. 113:383, 1939.Google Scholar
- 17.Winthrobe, M. M. Clinical Hematology. 4th ed. Lea & Febiger, Philadelphia, 1956, p. 505.Google Scholar
- 18.Ham, T. H. A Syllabus of Laboratory Examinations in Clinical Diagnosis. Harvard, Cambridge, Mass., 1958, p. 217.Google Scholar
- 19.Lee, R. I., andWhite, P. D. A clinical study of the coagulation time of blood.Am. J. M. Sc. 145:495, 1913.Google Scholar
- 20.Rees, H. M., Ecker, E. E. An improved method for counting platelets.J.A.M.A. 80:621, 1923.Google Scholar
- 23.Connor, W. E., andCarter, J. R. Influence of soybean phosphatide on blood coagulation and its use in the thromboplastin generation test.Proc. Soc. Exper. Biol. & Med. 97:38, 1958.Google Scholar
- 24.Quick, A. J., Stanley-Brown, M., andBancroft, F. W. A study of the coagulation defect in hemophilia and jaundice.Am. J.M. Sc. 190:501, 1935.Google Scholar
- 25.Quick, A. J. Hemorrhagic Diseases. Lea & Febiger, Philadelphia, 1957, p. 203.Google Scholar
- 27.Harrison, T. R. et. al. Principles of Internal Medicine. 3rd ed. McGraw-Hill, New York, 1953, p. 530.Google Scholar