Skip to main content
SpringerLink
Log in

Aspirin and gastric bleeding: Further studies of calcium aspirin

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

1. Soluble Calcium Aspirin has shown no significant signs of gastric irritation in 95 gastrectomy specimens. Standard aspirin has shown potentially serious gastric lesions in 8 out of 102.

2. Aspirin test meals have not shown a significant difference in the incidence of bleeding in 60 patients with histories of gastrointestinal disorders, half of whom were given soluble aspirin and the remainder standard aspirin.

3. Fecal occult blood studies, using Gregersen's method, have proved unreliable as a research weapon.

4. Calurin produced significantly less gastric bleeding than aspirin in 20 patients with no previous history of dyspepsia. (Calurin 5%, Aspirin 65%)

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wohlgemut, J. Uber aspirin (Acetylsalicylsauer).Therap. Monatsch. 13:276, 1899.

    Google Scholar 

  2. Douthwaite, A. H. Some recent advances in medical diagnosis and treatment.Brit. M. J. i:1143, 1938.

    Google Scholar 

  3. Douthwaite, A. H., andLintott, G. A. M. Gastroscopic observation of effect of aspirin and certain other substances on the stomach.Lancet ii:1222, 1938.

    Google Scholar 

  4. Muir, A., andCossar, I. A. Aspirin and ulcer.Brit. M. J. ii:7, 1955.

    Google Scholar 

  5. Muir, A., andCossar, I. A. Aspirin and gastric hemorrhage.Lancet i:539, 1959.

    Google Scholar 

  6. Lange, H. F. Salicylates and gastric hemorrhage.Gastroenterology 33:770, 1957.

    PubMed  Google Scholar 

  7. Stubbe, L. Th. F. L. Occult blood in faeces after administration of aspirin.Brit. M. J. ii:1062, 1958.

    Google Scholar 

  8. Alvarez, A. S., andSummerskill, W. H. J. Gastrointestinal hemorrhage and salicylates.Lancet ii:920, 1958.

    Google Scholar 

  9. Waterson, A. P. Aspirin and gastric hemorrhage.Brit. M. J. ii:1531, 1955.

    Google Scholar 

  10. Allibone, A., andFlint, F. J. Bronchitis, aspirin, smoking and other factors in the aetiology of peptic ulcer.Lancet ii:179, 1958.

    Google Scholar 

  11. Brown, R. K., andMitchell, N. The influence of some of the salicyl compounds (and alcoholic beverages) on the natural history of peptic ulcers.Gastroenterology 31:198, 1956.

    PubMed  Google Scholar 

  12. Kelly, J. J., Jr. Salicylate ingestion: A frequent cause of gastric hemorrhage.Am. J. Med. Sci. 232:191, 1956.

    Google Scholar 

  13. Schneider, E. M. Aspirin as a gastric irritant.Gastroenterology 33:616, 1957.

    PubMed  Google Scholar 

  14. Paul, W. D. Effect of acetylsalicylic acid (aspirin) on gastric mucosa; gastroscopic study.J. Iowa M. Soc. 33:155, 1943.

    Google Scholar 

  15. Smith, P. K., Gleason, H. L., Stoll, C. G., andOgorzalek, S. Studies on the pharmacology of salicylates.J. Pharmacol. & Exper. Therap. 87:237, 1946.

    Google Scholar 

  16. Smith, P. K. Certain aspects of the pharmacology of the salicylates.Pharmacol. Rev. 1:353, 1949.

    Google Scholar 

  17. Nelson, E., andSchaldemose, I. Urinary excretion kinetics for evaluation of drug absorption I. Solution rate limited and non-solution rate limited absorption of aspirin and benzyl penicillin, absorption rate of sulfathylthiadiazole.J. Am. Pharm. A. (Scien. Ed.) 48:489, 1959.

    Google Scholar 

  18. Nelson, E. Solution rate of theophylline salts and effects from oral administration.J. Am. Pharm. A. (Scient. Ed.) 16:607, 1947.

    Google Scholar 

  19. Nelson, E. Comparative dissolution rates of weak acids and their sodium salts.J. Am. Pharm. A. (Scient. Ed.) 47:297, 1948.

    Google Scholar 

  20. Nelson, E. Dissolution rates of mixtures of weak acids and tribasic sodium phosphate.J. Am. Pharm. A. (Scient. Ed.) 47:300, 1958.

    Google Scholar 

  21. Levy, G., andHayes, B. A. Physicochemical bases of buffered acetylsalicylic acid controversy.New England J. Med. 262:1053, 1960.

    Google Scholar 

  22. Batterman, R. C. Comparison of buffered and unbuffered acetylsalicylic acid.New England J. Med. 258:213, 1958.

    Google Scholar 

  23. Cronk, G. A. Laboratory and clinical studies with buffered and non-buffered acetylsalicylic acid.New England J. Med. 258:219, 1958.

    Google Scholar 

  24. Rubin, R. J., Pelikan, E. W., andKensler, C. J. Effects of unbuffered aspirin on intragastric pH.New England J. Med. 261:1208, 1959.

    Google Scholar 

  25. Paul, W. D., Dryer, R. L., andRouth, J. I. Effect of buffering agents on absorption of acetylsalicylic acid.J. Am. Pharm. A. (Scient. Ed.) 39:21, 1950.

    Google Scholar 

  26. Tebrock, H. E. Gastric tolerance for aspirin and buffered aspirin.Indust. Med. 20:480, 1951.

    Google Scholar 

  27. Fremont-Smith, P. Bufferin in the management of rheumatoid arthritis.J.A.M.A. 158:386, 1955.

    Google Scholar 

  28. Matsumoto, K. K., andGrossman, M. I. Quantitative measurement of gastrointestinal blood loss during ingestion of aspirin.Proc. Soc. Exper. Biol. & Med. 102:517, 1960.

    Google Scholar 

  29. Douthwaite, A. H. Effect of aspirin on the stomach.Lancet ii:917, 1954.

    Google Scholar 

  30. Watson, R. M., andPierson, R. N. Assay of gastrointestinal blood loss in subjects taking salicylates.Fed. Proc. 19:191, 1960.

    Google Scholar 

  31. Graham, J. D. P., andParker, W. A. The toxic manifestations of sodium salicylate therapy.Quart. J. Med. 17:153, 1948.

    Google Scholar 

  32. Caravati, C. M., andCosgrove, E. F. Salicylate toxicity: The probable mechanism of its action.Ann. Int. Med. 24:638, 1946.

    Google Scholar 

  33. Gross, M., andGreenberg, L. A. The “Salicylates.” Hillhouse Press, New Haven, 1948, p. 98.

    Google Scholar 

  34. Honigberger, M. Aspirin and gastric ulcer.Brit. M. J. ii:57, 1943.

    Google Scholar 

  35. Barbour, H. G., andDickerson, V. C. Gastric ulceration produced in rats by oral and subcutaneous aspirin.Arch. Internat. pharmacodyn 58:78, 1938.

    Google Scholar 

  36. Magnus, H. A. The pathology of simple gastritis.J. Path. & Bact. 58:431, 1946.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From Law Hospital, Carluke, Scotland

    Andrew Muir M.B., Ch.B. & Isabel A. Cossar M.B., Ch.B.

Authors
  1. Andrew Muir M.B., Ch.B.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Isabel A. Cossar M.B., Ch.B.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

We wish to thank Dorsey Laboratories for the Calurin tablets used in the study, and gratefully acknowledge the help given by Mr. W. J. M. Brandon for allowing us to investigate his patients; Dr. John Pettigrew, who photographed the specimens; Dr. R. I. Shaw Dunn and Dr. T. Lees for their preparation; and Mrs. E. C. A. McCrone for stenographic aid.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Muir, A., Cossar, I.A. Aspirin and gastric bleeding: Further studies of calcium aspirin. Digest Dis Sci 6, 1115–1125 (1961). https://doi.org/10.1007/BF02231809

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02231809

Keywords

Search

Navigation