Summary
The concentrations of sCD4 and sCD8 in 69 patients with systemic sclerosis (SSc) were examined by using a sandwich enzyme-linked immunosorbent assay. The patients with SSc had significantly higher concentrations of sCD8 (mean 249.2 U/ml (SD 155.1), median 224 U/ml) than the normal subjects (mean 149.3 U/ml (SD 42.1), median 148 U/ml). The concentration of sCD4 in patients with SSc were significantly lower (mean 6.2 U/ml (SD 3.8), median 5.0 U/ml) than in the normal subjects (mean 10.9 U/ml (SD 4.1), median 10.3 U/ml). The concentration of sCD8 in patients with diffuse sclerosis tended to be higher than in those with sclerodactyly.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Gupta, S., Malaviya, A.N., Rajagopalan, P., Good, R.A. Subsets of human T lymphocytes: imbalance of T cell population in patients with progressive systemic sclerosis. Clin Exp Immunol 1979, 38, 342–348.
Keystone, E.C., Lau, C., Gladman, D.D., Wilkinson, S., Lee, P., Shore, A. Immunoregulatory T cell subpopulations in patients with scleroderma using monoclonal antibodies. Clin Exp Immunol 1982, 48, 443–448.
Freundlich, B., Jimenez, A. Phenotype of peripheral blood lymphocytes in patients with progressive systemic sclerosis: activated T lymphocytes and the effect of D-penicillamine therapy. Clin Exp Immunol 1987, 69, 375–384.
Gustafsson, R., Tötterman, T.H., Klareskog, L., Hällgren, R. Increase in activated T cells and reduction in suppressor inducer T cells in systemic sclerosis. Ann Rheum Dis 1990, 49, 40–45.
Degiannis, D., Seibold, J.R., Czarnecki, M., Raskova, J., Raska, K. Soluble interleukin-2 receptors in patients with systemic sclerosis. Clinical and laboratory correlations. Arthritis Rheum 1990, 33, 375–380.
Tomkinson, B.E., Brown, M.C., Ip, S.H., Carrabis, S., Sullivan, J.L. Soluble CD8 during T cell activation. J Immunol 1989, 142, 2230–2236.
Pui, C., Ip, S.H., Dodge, R.K., Carrabis, S., Brown, M., Crist, W.M., Berard, C.W., Kung, P., Dahl, G.V., Murphy, S.B. Serum levels of CD8 antigen in childhood lymphoid malignancies: A possible indicator of increased suppressor cell activity in poor-risk patients. Blood 1988, 72, 1015–1021.
Furukawa, S., Matsubara, T., Tsuji, K., Motohashi, T., Okumura, K., Yabuta, K. Serum soluble CD4 and CD8 levels in Kawasaki disease. Clin Exp Immunol 1991, 86, 134–139.
Nouriaria, K.T., Lombard, M., Williams, R. High serum levels of CD8 antigen in primary biliary cirrhosis: a possible cause of suppressor cell dysfunction? Clin Exp Immunol 1991, 86, 140–144.
Symons, J.A., Wood, N.C., DiGiovine, F.S., Duff, G.W. Soluble CD8 in patients with rheumatic diseases. Clin Exp Immunol 1990, 80, 354–359.
Sawada, S., Sugai, S., Iijima, S., Takei, M., Paredes, E., Hayama, T., Nishimura, S., Hosokawa, Y., Horie, T., Obara, T. Increased soluble CD4 and decreased soluble CD8 molecules in patients with Sjögren's syndrome. Am J Med 1991, 92, 134–140.
Sawada, S., Iijima, S., Hashimoto, H., Tokano, Y., Takei, M., Shida, M., Horie, T., Obara, T. Increased soluble CD8, CD4 molecule in patients with systemic lupus erythematosus. J Rheumatol 1992, revised.
Subcommittee for scleroderma criteria for the American Rheumatism Association, diagnostic and therapeutic criteria committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980, 23, 581–590.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tokano, Y., Kaneko, H., Obara, T. et al. Soluble CD4 and CD8 molecules in patients with systemic sclerosis. Clin Rheumatol 12, 490–493 (1993). https://doi.org/10.1007/BF02231777
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02231777