Summary
Rheumatoid factor is of limited value in the diagnosis of rheumatoid arthritis (RA) in West Africa. Consequent upon previous findings, we have studied the role of the absence of antibodies to malaria and human immunodeficiency virus (HIV) as well as the presence of the hepatitis B surface antigen (HBsAg) as diagnostic markers of rheumatoid arthritis in West Africa. We have found a significant association (p<0.001) between RA and titre of HBsAg, but only between RA and malaria (p<0.05) when sera with low malaria antibodies were studied. No correlation between either HBsAg or malaria and rheumatoid factor was found and no RA patient was either HIV-1 or HIV-2 positive.
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Greenwood, B.M. Polyarthritis in Western Nigeria. I. Rheumatoid Arthritis. Ann Rheum Dis 1969, 28, 488–496.
Muller, A.S., Valkenburg, H.A., Greenwood, B.M. Rheumatoid arthritis in three West African populations. East Afr Med J 1972, 49, 75–83.
Waaler, E. On the occurrence of a factor in human sera activating specific agglutination of sheep blood corpuscles. Acta Pathol Microbiol Scand 1940, 17, 172–188.
Harris, E.D. Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med 1990, 322, 1277–1289.
Hijmans, W., Valkenburg, H.A., Muller, A.S., Gratamar, S. Rheumatoid arthritis in Liberia with an assessment of serological findings. Ann Rheum Dis 1964, 23, 45–49.
Houba, V., Bagg, L.R., Hansen, D.P., Bowry, T. Rheumatoid arthritis in Kenya. II. Serological observations. E Afr Med J 1978, 37, 26–30.
Greenwood, B.M., Muller, A.S., Valkenburg, H.A. Rheumatoid factor in Nigerian sera. Clin Exp Immunol 1971, 9, 161–173.
David, P., Stein, M., Ley, H., Johnston, C. Serological profiles in connective tissue diseases in Zimbabwean patients. Ann Rheum Dis 1989, 48, 73–76.
Ropes, M.W., Bennett, G.A., Cobb, S., Jacox, R., Jessor, R.A. Revision of diagnostic criteria in rheumatoid arthritis. Bull Rheum Dis 1959, 9, 175–176.
Adebajo, A.O., Cawston, T.E., Hazleman, B.L. Rheumatoid factor quantitation: a comparison of ELISA and nephelometric methods. Med Lab Sci 1991, 48, 47–51.
Adebajo, A.O., Birrell, F., Hazleman, B.L. The pattern of rheumatic disorders seen amongst patients attending urban and rural clinics in West Africa. Clin Rheumatol 1992, 11, 512–515.
Beighton, P., Solomon, L., Valkenburg, H.A. Rheumatoid arthritis in a rural South African Negro population. Ann Rheum Dis 1975, 34, 136–141.
Greenwood, B.M., Herrick, E.M., Voller, A. Can parasitic infection suppress autoimmune disease? Proc Roy Soc Med 1970, 63, 19–20.
Greenwood, B.M. Autoimmune disease and parasitic infections in Nigerians. Lancet 1968, ii, 380–382.
Greenwood, B.M., Voller, A. Suppression of autoimmune disease in New Zealand mice associated with infection with malaria. 1. (NZB × NZW F, hybrid mice). Clin Exp Immunol 1970, 7, 793–803.
Adebajo, A.O. Is rheumatoid arthritis an infectious disease. BMJ 1991, 303, 786.
Jacob, C.O. Tumour necrosis factorα in autoimmunity: pretty girl or old witch? Immunology Today 1992, 13, 122–125.
Greenwood, B.M., Herrick, E.M. Low incidence of rheumatoid factor and autoantibodies in Nigerian patients with rheumatoid arthritis. BMJ 1970, 1, 71–73.
De Cock, K.M., Barrere, B., Diaby, L. et al. AIDS — the leading cause of adult death in the West African city of Abidjan, Ivory Coast. Science 1990, 249, 793–796.
Anderson, R.M., May, R.M., Boily, M.C., Garnett, G.P., Rowley, J.T. The spread of HIV-1 in Africa: sexual contact patterns and the predicted demographic impact of AIDS. Nature 1991, 352, 581–589.
Kerr, L.D., Spiera, H. The coexistence of active classic rheumatoid arthritis and AIDS. J Rheumatol 1991, 18, 1739–1740.
Berman, A., Reboredo, G., Spindler, A., Lasala, M.E., Lopez, H., Espinoza, L.R. Rheumatic manifestations in populations at risk for HIV infection: The added effect of HIV. J Rheumatol 1991, 18, 1564–1567.
Bijlsma, J.W.J., Dersken, R., Huber-Bruning, O., Borleffs, J.C. Does AIDS ‘cure’ rheumatoid arthritis. Ann Rheum Dis 1988, 47, 350.
Calabrese, L.H., Wilkes, W.S., Perkins, A.D., Tubbs, R.R. Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjogren's syndrome. Arthritis Rheum 1989, 32, 1453–1457.
Clavel, F. HIV-2, the West African AIDS virus. AIDS 1987, 1, 135–140.
Clavel, F., Guetard, D., Brun-Vezinet, F. et al. Isolation of new human retrovirus from a West African with AIDS. Science 1986, 233, 343–346.
Bossier, M., Lefrere, J., Dreyfus, P. Rheumatic manifestation in a patient with human immunodeficiency virus type 2 infection. Arthritis Rheum 1991, 34, 790.
Holligan, S., Birrell, F., Adebajo, A.O., Asuzo, M., Thomson, W., Olier, W.E.R., Silman, A.J. Low prevalence of rheumatoid arthritis in a rural Nigerian population. Br J Rheum 1991, 30, 1.
Szmuness, W., Prince, A.M., Diebolt, G., Leblanc, L., Baylet, L., Masseyeff, R., Linhard, J. The epidemiology of hepatitis B infection in Africa: results of a pilot survey in the Republic of Senegal. Am J Epid 1973, 98, 104–110.
Olumide, E.A. The distribution of hepatitis B surface antigen in Africa and the tropics: report of a population study in Nigeria. Int J Epidemiol 1976, 5, 279–289.
Greenwood, B.M., Whittle, H.C. Immunology in the Tropics. Edward Arnold Ltd., London, 1981, 1–20.
Zigenfuss, J.F., Miller, F., Rassman, D. Rheumatoid factor and Australia antigen. N Engl J Med 1971, 284, 1104.
State, I., Rungan, V., Voiculescu, M., State, D. Rheumatoid factor and Australia antigen in acute and chronic hepatitis. Rev Rum Med Int 1973, 10, 29–36.
Dudley, F.J., O'Lea, M.J., Sherlock, S. Serum autoantibodies in hepatitis associated antigen (HAA) positive patients. Clin Exp Immunol 1973, 13, 367–372.
Wantanabe, K., Ohkubo, Y., Funahashi, Y. et al. An investigation on rheumatoid factor of different immunoglobulin classes in hepatitis B virus carriers. Clin Rheum 1991, 10, 31–37.
Leyva, A., Bernal, M.C., Piedrola, G., Maroto, M.C. A study of the evolution of specific and non-specific immune complexes in acute hepatitis B and chronic hepatitis. J Med Microbiol 1988, 26, 237–239.
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Adebajo, A.O., Hazleman, B.L. The absence of antibodies to malaria and human immunodeficiency virus, and the presence of hepatitis B surface antigen as diagnostic markers of rheumatoid arthritis. Clin Rheumatol 12, 467–470 (1993). https://doi.org/10.1007/BF02231772
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DOI: https://doi.org/10.1007/BF02231772