Summary
Secondary causes and risk factors assume far greater importance in male osteoporosis than in female osteoporosis. The principal problem in dealing with male osteoporosis, above all in young men, is the difficulty to find a curable aetiology. Six groups of aetiologies can be drawn up: toxic causes or causes due to a change in the general state of health, drug-induced causes, renal causes, hormonal causes, exceptional causes and lastly the idiopathic form. The minimum number of investigations necessary so as to be quite sure not to overlook these various aetiologies is proposed.
Similar content being viewed by others
References
Adland-Davenport, P., McKenzie, M.W., Notelovitz, M., McKenzie, Pendergast, J.F. Thiazide diuretics and bone mineral content in postmenopausal women. Am J Obstet Gynecol, 1985, 152–156, 630–634.
Alevizaki, M., Stenvenson, J.C., Girgis, S.I., MacIntyre, I., Legon, S. Altered calcitonin gene in a young patient with osteoporosis. Br Med J 1989, 298 (6682), p. 1215–1216.
Alhava, E.M., Juuti, M., Karjalainen, P. Bone mineral density in patients with urolithiasis. Scand J Urol Nephrol. 1976, 10, 154–156.
Barkin, J., Wilson, D.R., Manuel, A., Bayley, A., Murray, T., Harrison. Bone mineral content in idiopathic calcium nephrolithiasis. Mineral Electrolyte Metab 1985, 11, 19–24.
Bikle, D.D., Genant, H.K., Cann, C., Recker, R., Halloran, B.P., Strewler, G.J. Bone disease in alcohol abuse. Ann Int Med 1985, 103, 42–48.
Bourdel, A., Mahoudeau, J.A., Guaydier-Souqières, G., Leymarie, P., Sabatier, J.P., Loyau G. Etude de la fonction gonadique au cours de l'ostéoporose masculine en apparence primitive. Press Med 1989, 18, 34, 1691–1694.
Coe, F.L., Parks, J.H., Bushinsky, D.A., Langman, C.B., Favus, M.J. Chlorthalidone promotes mineral retention in patients with idiopathic hypercalciuria. Kidney Int 1988, 33, 1140–1146.
Daragon, A., Dhib, M., Morin, J.P., Godin, M., Fillastre, J.P. Hypercalciurie idiopathique et densité osseuse. Rev Rhum Mal Osteoartic, 1992, 59-1, 35–38.
De Vernejoul, M.C., Bielakoff, J., Herve, M., Gueris, J., Hott, M., Modrowski, D., Kuntz, D., Miravet, L., Ryckewaert, A. Evidence for defective osteoblastic function. A role for alcohol and tobacco consumption in osteoporosis in middle-aged men. Clinic Orthop, 1983, 179, 107–115.
Diamond, T., Stiel, D., Posen, S. Osteoporosis in hemochromatosis: iron excess, gonadal deficiency, or other factors? Ann Int Med 1989, 110-6, 430–436.
Duquesnoy, B., Noel, C., Hubaud, P., Beuscart, R., Delcambre, B. Métabolisme phosphocalcique et histomorphométrie osseuse dans l'éthylisme chronique. A propos de 25 cas. Rev Rhum Mal Osteoartic 1984, 51, 2, 75–80.
Duquesnoy, B., Flipo, R.M., Leroy, R., Wemeau, J.L. Ostéopathies endocriniennes. Editions Techniques. Encycl Méd Chir (Paris-France), Appareil Locomoteur, 14025 A10, 5-1990, 10.
Feitelberg, S., Epstein, S., Ismail, F., D'Amanda, C. Deranged bone mineral metabolism in chronic alcoholism. Metabolism 1987, 36, 4, 322–326.
Finkelstein, J.S., Klibanski, A., Neer, R.M., Greenspan, S., Rosenthal, D.I., Crowley, W.J. Osteoporosis in men with idiopathic hypogonadotropic hypogonadism. Ann Int Med 1987, 106, 354–361.
Finkelstein, J.S., Klibanski, A., Neer, R., Doppelt, H., Rosenthal, D.L., Segre, G.V., Crowley, W.F. Increases in bone density during treatment of men with idiopathic hypogonadotrophic hypogonadism. J Clin Endocrinol Metab, 1989, 69-4, 776–782.
Finkelstein, J.S., Neer, R.M., Biller, B.M.K., Crawford, J.D., Klibansky, A. Osteopenia in men with a history of delayed puberty. N Eng J Med 1992, 326, 600–604.
Foresta, C., Scanelli, G., Zanatta, G.P., Busnardo, B., Scandellari, C. Reduced calcitonin reserve in young hypogonadic osteoporotic men. Horm Metab Res 1987, 19(6), 275–277.
Foresta, C., Ruzza, G., Mioni, R., Meneghello, A., Baccichetti, C. Testosterone and bone loss in Klinefelters syndrome. Horm Metabol Res 1983, 15, 56–57.
Francis, R.M., Peacock, M., Marshall, D.H., Horsman, A., Aaron, J.E. Spinal osteoporosis in men. Bone Miner. 1989, 5, 347–357.
Greenspan, S.L., Neer, R.N., Ridgway, E.C., Klibanski, A. Osteoporosis in men with hyperprolactinemic hypogonadism. Ann Intern Med 1986, 104, 777–782.
Hardouin, P., Sutter, B. Ostéopathies cortisoniques. Editions techniques. Encycl. Méd Chir Paris-France. Appareil locomoteur, 14025 B10, 5-1990, 4.
Hills, E., Dunstan, C.R., Wong, S.Y.P., Evans, R. A. Bone histology in young adult osteoporosis. J Clin Pathol 1989, 42, 391–397.
Horlait, S., Bard, H., Bardin, T. Ostéoporose juvénile idiopathique. In l'actualité rhumatologique présentée au praticien. De Sèze, S., Ryckewaert, A., Khan, M.F., Guérin, Cl. Expansion scientifique française 1987.
Jackson, J.A., Kleerekoper, M. Osteoporosis in men: Diagnosis, pathophysiology, and prevention. Medecine, 1990, 69, 3, 137–152.
Jackson, J.A., Kleerekoper, M., Parfitt, A.M., Rao, D.S., Villanueva, A.R., Frame, B. Bone histomorphometry in hypogonadal and eugonadal men with spinal osteoporosis. J Clin Endocrinol Metab 1987, 65, 1, 53–58.
Johnell, O., Nilsson, B.E., Wiklund, P.E. Bone histomorphometry in alcoholics. Clin Orthop 1982, 165, 253–258.
Kelly, P.J., Pocock, N.A., Sambrook, P.N., Eisman, J.A. Dietary calcium, sex hormones, and bone mineral density in men. Br Med J 1990, 300, 1361–1364.
Kuntz, J.L., Caillard, C., Werle, Cl., Bloch, J.G., Simon, Ch., Asch, L. Ostéoporose avec déficit androgénique chez un marcheur. Rev Rhum Mal Osteoartic 1990, 57, 1, 5–7.
Lacroix, A.Z., Wienpahl, J., White, L.R., Wallace, R.B., Scherr, P.A., George, L.K., Cornony-Huntley, J., Ostfeld, A.M. Thiazide diuretic agents and the incidence of hip fracture. N Engl J Med 1990, 322, 286–290.
Laroche, M., Arlet, J., Ader, Jl., Durand, Arlet, Ph., Cantagrel, A., Tran-Van, T., Mazières, B. Ostéoporose masculine, une étiologie méconnue: la tubulopathie proximale idiopathique modérée. Rev Rhum Mal Osteoartic, 1992, 59-1, 3–9.
Lemann, J., Gray, R.W. Idiopathic hypercalciuria. J Urology 1989, 141, 715–718.
Lawoyin, S., Sismilich, S., Browne, R., Pak, C.Y. Bone mineral content in patients with calcium urolithiasis. Metabolism 1979, 28-12, 1250–1254.
Meier, D.E., Orwoll, E.S., Jones, J.M. Marked disparity between trabecular and cortical bone loss with age in healthy men. Measurement by computed tomography and radial photon absorptiometry. Ann Inter Med 1984, 101, 605–612.
Meunier, P., Dechavanne, M., Prost, G., Edouard, C., Bernard, J., Coupron, P., Tolot, F. L'os des cirrhotiques étudié par lecture quantitative de la biopsie osseuse. Lyon Médical 1973, 229, 11, 1089–1095.
Orwoll, E.S., Oviatt, S.K., McClung, M.R., Deftos, L.J., Sexton, G. The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation. Ann Internal Med 1990, 112-1, 29–34.
Patri, B., Le Chapentier, Y., Guéris, J., Calmettes, Cl., Dubrisay, J. Vitamine D, parathormone, calcitonine et histomorphométrie osseuse chez les cirrhotiques. Rev Rhum Mal Ostéoartic 1978, 45, 11, 631–640.
Rico, H., Cabranes, J.A., Cabello, J., Gomez-Castresana, F., Hernandez, E.R. Low serum osteocalcin in acute alcohol intoxication: a direct toxic effect of alcohol on osteoblasts. Bone Mineral 1987, 2, 221–225.
Rigotti, N.A., Neer, R.M., Jameson, L. Osteopenia and bone fractures in a man with anorexia nervosa and hypogonadism. JAMA 1986, 256, 3, 385–388.
Seeman, E., Melton, J., Michael, O'Fallon, Riggs, B.L. Risk factors for spinal osteoporosis in men. Am J Med 1983, 75, 977–983.
Smith, D.A.S., Walker, M.S. Changes in plasma steroids and bone density in Klinefelter's syndrome. Calcif Tissue Res 1976, 22 (suppl), 225–228.
Spencer, H., Rubio, N., Rubio, E., Indreika, M., Seitam, A. Chronic alcoholism. Am J Med 1986, 393–397.
Transbol, I., Christensen, M.S., Jensen, J.F., Christiansen, C., McNair, P. Thiazide for the postponement of postmenopausal bone loss. Metabolism 1982, 31, 383–386.
Tsouderos, Y. Modifications du métabolisme osseux et phosphocalcique de l'alcoolisme chronique. Concours Médical, 1982, 104–107.
Van Thiel, D.H., Lester, R. Sex and Alcohol. N Engl J Med 1974, 291, 251–253.
Wanish, R.D., Benfante, R.J., Katsuhiko, Y., Heibrun, L., Vogel, J.M. Thiazide effect on the mineral content of bone. N Engl J Med 1983, 309, 344–347.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mattei, J.P., Arniaud, D., Tonolli, I. et al. Aetiologies of male osteoporosis: Identification procedures. Clin Rheumatol 12, 447–452 (1993). https://doi.org/10.1007/BF02231769
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02231769