The American Journal of Digestive Diseases

, Volume 17, Issue 7, pp 639–642 | Cite as

The effect of antibiotic drugs on the volume and composition of intestinal gas from beans

  • Edwin L. Murphy
  • Doris Howes Calloway


Healthy men were confined to a metabolic unit and fed bean meals to stimulate intestinal gas formation while under antibiotic medication. Periodic samples of flatus and breath were collected after the test meal for gas chromatographic analysis. Succinylsulfathiazole administration resulted in a two- to fourfold increase in intestinal hydrogen excretion in all subjects, while iodochlorhydroxyquin medication significantly reduced hydrogen excretion from the level of a bean meal to that of a bland diet. Neomycin reduced the hydrogen level in half of the subjects and raised it in the others. Thus, these antibiotic drugs can alter the activity of hydrogen-producing microorganisms.


Periodic Sample Chromatographic Analysis Neomycin Test Meal Fourfold Increase 
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    Calloway DH, Murphy EL, Bauer D: Determination of lactose intolerance by breath analysis. Am J Dig Dis 14:811, 1969PubMedGoogle Scholar

Copyright information

© Harper & Row, Publishers 1972

Authors and Affiliations

  • Edwin L. Murphy
    • 1
    • 2
  • Doris Howes Calloway
    • 2
  1. 1.Agricultural Research Services, USDAWestern Marketing and Nutritional Research DivisionAlbany
  2. 2.Department of Nutritionál SciencesUniversity of CaliforniaBerkeley

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