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The American Journal of Digestive Diseases

, Volume 17, Issue 7, pp 639–642 | Cite as

The effect of antibiotic drugs on the volume and composition of intestinal gas from beans

  • Edwin L. Murphy
  • Doris Howes Calloway
Article

Abstract

Healthy men were confined to a metabolic unit and fed bean meals to stimulate intestinal gas formation while under antibiotic medication. Periodic samples of flatus and breath were collected after the test meal for gas chromatographic analysis. Succinylsulfathiazole administration resulted in a two- to fourfold increase in intestinal hydrogen excretion in all subjects, while iodochlorhydroxyquin medication significantly reduced hydrogen excretion from the level of a bean meal to that of a bland diet. Neomycin reduced the hydrogen level in half of the subjects and raised it in the others. Thus, these antibiotic drugs can alter the activity of hydrogen-producing microorganisms.

Keywords

Periodic Sample Chromatographic Analysis Neomycin Test Meal Fourfold Increase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Calloway DH: Gas in the alimentary canal. chap 137, Alimentary Canal, Sec VI. Vol 5, Handbook of Physiology. American Physiological Society, 1968, pp 2839–2859Google Scholar
  2. 2.
    Calloway DH, Murphy EL: The use of expired air to measure intestinal gas formation. Ann NY Acad Sci 150:82, 1968PubMedGoogle Scholar
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    Hickey CA, Calloway DH, Murphy EL: Intestinal gas production following ingestion of fruits and fruit juices. Am J Dig Dis 17:383–388, 1972CrossRefPubMedGoogle Scholar
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    Sackmann W, Kradolfer F: Directed influence on the intestinal flora by means of Mexaform and chlortetracycline. Schweiz Med Wochenschr 92:50, 1962PubMedGoogle Scholar
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    Calloway DH, Murphy EL, Bauer D: Determination of lactose intolerance by breath analysis. Am J Dig Dis 14:811, 1969PubMedGoogle Scholar

Copyright information

© Harper & Row, Publishers 1972

Authors and Affiliations

  • Edwin L. Murphy
    • 1
    • 2
  • Doris Howes Calloway
    • 2
  1. 1.Agricultural Research Services, USDAWestern Marketing and Nutritional Research DivisionAlbany
  2. 2.Department of Nutritionál SciencesUniversity of CaliforniaBerkeley

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