The effect of antibiotic drugs on the volume and composition of intestinal gas from beans
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Healthy men were confined to a metabolic unit and fed bean meals to stimulate intestinal gas formation while under antibiotic medication. Periodic samples of flatus and breath were collected after the test meal for gas chromatographic analysis. Succinylsulfathiazole administration resulted in a two- to fourfold increase in intestinal hydrogen excretion in all subjects, while iodochlorhydroxyquin medication significantly reduced hydrogen excretion from the level of a bean meal to that of a bland diet. Neomycin reduced the hydrogen level in half of the subjects and raised it in the others. Thus, these antibiotic drugs can alter the activity of hydrogen-producing microorganisms.
KeywordsPeriodic Sample Chromatographic Analysis Neomycin Test Meal Fourfold Increase
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- 1.Calloway DH: Gas in the alimentary canal. chap 137, Alimentary Canal, Sec VI. Vol 5, Handbook of Physiology. American Physiological Society, 1968, pp 2839–2859Google Scholar