Summary
Two cases of Behçet's disease associated with myelodysplastic syndrome are described. Both patients showed a chromosomal abnormality, trisomy 8. Based on the laboratory findings in our patients and a careful review of the literature of similar cases, the association of the chromosomal abnormality with the pathogenesis of Behçet's disease is suggested.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Efthimiou, J., Addison, I.E., Jhonson, B.V. In vivo leukocyte migration in Behçet's syndrome. Ann Rheum Dis 1989, 48, 206–210.
Niwa, Y., Miyake, S., Sakane, T., Shingu, M., Yokogawa, M. Auto-oxidative damage in Behçet's disease: endothelial cell damage following stimulated neutrophils. Clin Exp Immunol 1982, 49, 247–255.
Yoshida, Y., Stephenson, J., Mufti, G.J. Myelodysplastic syndromes -from morphology to molecular biology -. Int J Hematol 1993, 57, 87–97.
Yuo, A., Kitagawa, S., Okabe, T. Recombinant human granulocyte colony- stimulating factor repairs the abnormalities of neutrophils in patients with myelodysplastic syndromes and chronic myelogenic leukemia. Blood 1987, 70, 404–411.
Nehashi, Y., Torii, Y., Yaguchi, M., Iteh, Y., Ohyashiki, K., Toyama, K. Incomplete form of Behçet's disease in a case of monopathic myelodysplastic syndrome presenting as a thrombocytopenia. Jpn J Clin Hematol (Jpn) 1988, 29, 1097–1102.
Nakayama, S., Ishikawa, T., Yabe, H., Naagai, K. Refractory anemia complicated by Behçet's disease — Report of three cases. Jpn J Clin Hematol (Jpn) 1989, 30, 530–534.
Takishita, N., Horiuchi, T., Hato, T., Fujita, S., Kobayashi, Y. Myelodysplastic syndrome complicated with Behçet's disease. Ehime Medicine (Jpn) 1991, 11, 39–43.
Chyuma, Y., Utunomiya, A., Saito, T., Hanada, S., Nishimata, H., Arima, T. Hemolytic anemia complicated with Behçet's disease and myelodysplastic syndrome. Jpn J Clin Hematol (Jpn) 1991, 33, 333–337.
Yoshizawa, Y., Hirai, A., Izaki, S., Kitamura, K. Two cases of Behçet's disease complicated with bone marrow diseases. Rynsho Derma (Jpn) 1992, 34, 1585–1589.
Solé, F., Prieto, F., Badia, L., Woesnner, S., Florensa, L., Caballin, M.R., Coll, M.D., Besses, C., Sans-Sabrafen, J. Cytogenetic studies in 112 cases of untreated myelodysplastic syndromes. Cancer Genet Cytogenet 1992, 64,12–20.
Weschsler, B., Davatchi, F., Mizushima, Y., Hamza, M., Dilsen, E., Kansu, H., et al. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990, 335, 1078–1080.
Bennet, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R., et al. The French-American British (FAB) Co-operative Group. Proposals for the classification of the myelodysplastic syndromes. Br J Hemat 1982, 51, 189–199.
Stephenson, J., Mufti, G.J., Yoshida, Y. Myelodysplastic syndromes -from morphology to molecular biology -. Int J Hematol 1993, 57, 99–112.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yano, K., Eguchi, K., Migita, K. et al. Behçet's disease complicated with myelodysplastic syndrome a report of two cases and review of the literature. Clin Rheumatol 15, 91–93 (1996). https://doi.org/10.1007/BF02231696
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02231696