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Comparison between the effect of pentagastrin and Histalog on gastric acid secretion

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Abstract

Fifty subjects with a wide range of maximal gastric secretory output were tested, using Histalog (2.5 mg/kg intramuscularly) as the stimulant on one day and pentagastrin (6 µg/kg subcutaneously) on another day. Gastric output was collected for 2 hours after each injection. The pentagastrin test used in this study gave virtually the same value for 30-minute acid output as the Histalog test and could be shortened to 45 minutes post-injection without loss of accuracy. The side effects of pentagastrin were trivial and transitory.

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Authors and Affiliations

  1. Department of Surgery, University of British Columbia, Vancouver General Hospital, Vancouver 9, BC, Canada

    I. G. M. Cleator MB, ChBEd (FRCSE, FRCS), J. L. Stoller MB (FRCSE, FRCSC), F. R. C. Johnstone MB (FACS, FRCSE), I. B. Holubitsky MD (FRCS(C), FACS) &  R. C. Harrison MD, MS (FRCS(C), FACS)

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  1. I. G. M. Cleator MB, ChBEd
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  2. J. L. Stoller MB
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  3. F. R. C. Johnstone MB
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  4. I. B. Holubitsky MD
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  5. R. C. Harrison MD, MS
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Cleator, I.G.M., Stoller, J.L., Johnstone, F.R.C. et al. Comparison between the effect of pentagastrin and Histalog on gastric acid secretion. Digest Dis Sci 17, 713–719 (1972). https://doi.org/10.1007/BF02231639

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  • DOI: https://doi.org/10.1007/BF02231639

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