The American Journal of Digestive Diseases

, Volume 17, Issue 8, pp 713–719 | Cite as

Comparison between the effect of pentagastrin and Histalog on gastric acid secretion

  • I. G. M. Cleator
  • J. L. Stoller
  • F. R. C. Johnstone
  • I. B. Holubitsky
  • R. C. Harrison


Fifty subjects with a wide range of maximal gastric secretory output were tested, using Histalog (2.5 mg/kg intramuscularly) as the stimulant on one day and pentagastrin (6 µg/kg subcutaneously) on another day. Gastric output was collected for 2 hours after each injection. The pentagastrin test used in this study gave virtually the same value for 30-minute acid output as the Histalog test and could be shortened to 45 minutes post-injection without loss of accuracy. The side effects of pentagastrin were trivial and transitory.


Public Health Gastric Acid Acid Secretion Gastric Acid Secretion Acid Output 
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Copyright information

© Harper & Row, Publishers 1972

Authors and Affiliations

  • I. G. M. Cleator
    • 1
  • J. L. Stoller
    • 1
  • F. R. C. Johnstone
    • 1
  • I. B. Holubitsky
    • 1
  • R. C. Harrison
    • 1
  1. 1.Department of SurgeryUniversity of British Columbia, Vancouver General HospitalVancouver 9Canada

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