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Clinical Rheumatology

, Volume 12, Issue 1, pp 93–94 | Cite as

Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate

  • B. Taillan
  • G. Garnier
  • J. Castanet
  • E. Ferrari
  • A. Pesce
  • P. Dujardin
Case Report

Summary

We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.

Key words

Lymphoma Methotrexate Rheumatoid Arthritis 

References

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    Kinlen, L.J. Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. Am J Med 1985, (suppl 1A) 78, 44–49.CrossRefGoogle Scholar
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    Ellman, M.H., Hurwitz, H., Thomas, C., Kozloff, M. Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate. J Rheumatol 1991, 18, 1741–1743.PubMedGoogle Scholar
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    Bailin, P.L., Tindall, J.P., Roenigh, H.H. et al. Is methotrexate therapy for psoriasis carcinogenic? A modified retrospective prospective analysis. JAMA 1975, 232, 359–362.CrossRefPubMedGoogle Scholar
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    Shiroky, J.B., Frost, A., Skelton, J.D. et al. Complications of immunosuppression associated with weekly low dose methotrexate. J Rheumatol 1991, 18, 1172–1175.PubMedGoogle Scholar

Copyright information

© Acta Medica Belgica 1993

Authors and Affiliations

  • B. Taillan
    • 1
  • G. Garnier
    • 1
  • J. Castanet
    • 1
  • E. Ferrari
    • 1
  • A. Pesce
    • 1
  • P. Dujardin
    • 1
  1. 1.Service de Médecine InterneHôpital de CimiezNice Cedex 1France

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