The American Journal of Digestive Diseases

, Volume 2, Issue 11, pp 663–668 | Cite as

Evidence of increased intestinal absorption of molecular sucrose in sprue

  • Rafael SantiniJr.
  • E. Perez-Santiago
  • Jose Martinez-de Jesus
  • C. E. ButterworthJr.
Article

Summary

It has been found that patients with sprue excrete significantly greater quantities of intact sucrose in the urine after an oral dose of sucrose than do normal subjects. The urine of normal persons becomes free of sucrose after a 10-hour fast, but patients with sprue may exhibit sucrosuria throughout a 24-hour fast. Diminished hydrolysis of sucrose and increased intestinal permeability are mentioned as possible explanations for the findings.

Keywords

Public Health Permeability Hydrolysis Sucrose Oral Dose 

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References

  1. 1.
    Moyer, J. H., andWomack, C. R. Glucose tolerance tests.Texas J. Med. 46:763, 1950.PubMedGoogle Scholar
  2. 2.
    Gardner, F. H. A malabsorption syndrome in military personnel in Puerto Rico.A.M.A. Arch. Int. Med. 98:44, 1956.Google Scholar
  3. 3.
    Maegraith, B. G.,et al.. Carbohydrate absorption in Sprue.Lancet 2:635, 1945.CrossRefGoogle Scholar
  4. 4.
    Fox, H. J. Sucrose absorption in sprue.J. Lab. & Clin. Med. 35:622, 1950.Google Scholar
  5. 5.
    Althausen, T. L. A test for intestinal absorption.Am. J. Digest. Dis. 6:544, 1939.Google Scholar
  6. 6.
    Brien, F. S., et al. Study of carbohydrate and fat absorption from normal and diseased intestine in man: I. Absorption and excretion ofd-xylose.Gastroenterology 20:287, 1952.PubMedGoogle Scholar
  7. 7.
    Benson, J. A., Jr.,et al. Thed-xylose absorption test in malabsorption syndromes.New England J. Med. 256:335, 1957.Google Scholar
  8. 8.
    Gardner, F. H., andPerez-Santiago, E. Oral absorption tolerance tests in tropical sprue.A.M.A. Arch. Int. Med. 98:467, 1956.Google Scholar
  9. 9.
    Nelson, N. A photometric adaptation of the Somogyi method for the determination of glucose.J. Biol. Chem. 153:375, 1944.Google Scholar
  10. 10.
    Deane, N., andSmith, H. W. Fate of inulin and sucrose in normal subjects as determined by a urine reinfusion technique.J. Clin. Invest. 34:681, 1955.PubMedGoogle Scholar
  11. 11.
    Butterworth, C. E., Jr., andPerez-Santiago, E. Jejunal Biopsies in sprue.Ann. Int. Med. (To be published).Google Scholar
  12. 12.
    Lahdensuu, S. On blood sugar curves and saccharosuria in children due to saccharose tolerance test.Ann. Med. Int. Fenniae 36:293, 1947.Google Scholar

Copyright information

© Paul B. Hoeber, Inc. 1957

Authors and Affiliations

  • Rafael SantiniJr.
    • 1
  • E. Perez-Santiago
    • 1
  • Jose Martinez-de Jesus
    • 1
  • C. E. ButterworthJr.
    • 1
  1. 1.From the U. S. Army Tropical Research Medical LaboratorySan JuanP. R.

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