Conclusions
1. The incidence of peptic ulcer in patients with cirrhosis is higher than in the general hospital population. The incidence increases in relation to the severity of cirrhosis.
2. Perforation of an ulcer is always a danger and appears to be more serious than the more frequently reported complication of hemorrhage.
3. Danger of perforation appears to be greater following paracentesis.
4. Successful management of this emergency is based on the diagnostic consideration of perforation in a patient who develops shock or abdominal pain shortly following paracentesis. Ascites and bleeding were frequently associated with the perforation. Diagnostic aids include performance of a diagnostic tap and roentgen examination of the abdomen for free air.
5. If the diagnosis can be made, surgical intervention is indicated since the mortality rate is certain to be less following surgical treatment than expectant medical care.
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References
Antonini, R., andMarinoni, F. Sulla associazione cirrosi hepatica ulcerazione gastroduodenale.La Clinica 14:184, 1953.
Askanazy, M. Befunde und Gedanken zu den Problemen der Leberzirrhose.Schweiz. med. Wchnschr 12:961, 1931.
Ask-Upmark, E. Further observations on the pathogenesis of peptic ulcer.Acta med. scandinav. 103:280, 1940.
Barborka, C. J., andTexter, E. C., Jr. Peptic Ulcer: Diagnosis and Treatment. Boston, Little, 1955, pp. 48–50.
Bjorneboc, M., andRoaschou, F. The pathology of subchronic atrophy of liver: A comparison with Laennec's hepatic cirrhosis.Acta med. scandinav. Supp.234:41, 1949.
Borden, C. W., andTexter, E. C., Jr. (Eds.): Medical grand rounds: Hepatic coma.Am. J. Digest. Dis. N.S. 3: February 1958.
Brandstäter, P. Das Bild einer Perforationsperitonitis bei Leberzirrhose.Zentralbl. Chir. 80:626, 1955.
Brody, D. A., andQuigley, J. P. Intralumen pressure of the stomach and duodenum in health and disease.Gastroenterology 9:570, 1947.
Chapman, W. P., Herrera, R., andJones, C. M. A comparison of pain produced experimentally in lower esophagus, common bile duct and upper small intestine with pain experienced by patients with disease of biliary tract and pancreas.Surg. Gynec. & Obst. 89:573, 1949.
Dagradi, A., Sanders, D., andStempin, S. F. The upper gastrointestinal bleeding in liver cirrhosis.Ann. Int. Med. 42:852, 1955.
Davidson, C. S. “Hepatic Coma,” inDock, W., andSnapper, I. (Eds.):Advances in Internal Medicine. Chicago, Yrbk. Pub., 1955, Vol. VII, pp. 33–63.
Duomarco, J., andRimini, R. La presión intraabdominal en la ascitis.Arch. urug. med. 29:450, 1946.
Ebert, R. V., Hagen, P. S., andBorden, C. W. The mechanism of shock in peritonitis: A study of the hemodynamics of shock occurring in peritonitis experimentally produced in dogs.Surgery 25:399, 1949.
Fainer, D. C., andHalstead, J. A. Sources of upper alimentary tract hemorrhage in cirrhosis of liver.J.A.M.A. 157:413, 1955.
Garnier, M. M. Les peritonitis aigues au cours des cirrhosis du foie avec ascite.Bull. et mém. Soc. méd. hôp. Paris 50:348, 1926.
Giges, B., andKunkel, H. G. Osmotic pressure measurements of serum and ascitic fluid in patients with cirrhosis of the liver.J. Clin. Invest. 33:257, 1954.
Gilbert, R. P., andTexter, E. C., Jr. (Ed.): Medical grand rounds of Veterans Administration Research Hospital: II. Bacteremic shock.Quart. Bull. Northwestern Univ. M. School 30:356, 1956.
Hyatt, R. E., andSmith, J. R. The mechanism of ascites—a physiologic appraisal.Am. J. Med. 16:434, 1954.
Ivy, A. C., Grossman, M. I., andBachrach, W. H. Peptic Ulcer. Philadelphia, Blakiston, 1950, pp. 294–296.
Jiminez-Diaz, C. Cirrosis hepatica, ulcera duodenale.Rev. clin. españ. 57:55, 1955.
Lipp, W. F., andLipsitz, M. H. The clinical significance of the coexistence of peptic ulcer and portal cirrhosis with special reference to the problem of massive hemorrhage.Gastroenterology 22:186, 1952.
Palmer, E. D., andBrick, I. B. Sources of upper gastrointestinal hemorrhage in cirrhotic patients with esophageal varices.New England J. Med. 248:1057, 1953.
Pallasse, E., andGauldon. Considerations sur la tensión intraabdominale dans l'ascite.Lyon med. 131:803, 1922.
Pitsoris, G. Peritonitis bei leberzirrhose.Deutsche. med. Wchnschr. 58:296, 1932.
Pollack, H., andInman, C. E. Hepatic dysfunction in peptic ulcer: Observations with the hippuric acid test.Lancet 2:131, 1947.
Puccini, C. Le alterazioni gastro-duodenali in corso de ipertensione cronica portale in base allo studio di 27 osservozioni autopische.Arch. “de Vecchi” anat. pat. 14:413, 1950.
Quigley, J. P., andBrody, D. A. A physiologic and clinical consideration of the pressures developed in the digestive tract.Am. J. Med. 13:73, 1952.
Ratnoff, O. D., andPatek, A. J., Jr. The natural history of Laennec cirrhosis of the liver: An analysis of 386 cases.Medicine 21:207, 1942.
Schnitker, M. A., andHass, G. M. A histologic study of the liver in patients affected with peptic ulcerAm. J. Digest Dis. & Nutrit. 1:537, 1934.
Smith, H. W., andTexter, E. C., Jr. Characteristics of the phasic intraluminal pressure waves from the stomach and duodenum: Studies in normal subjects and ulcer patients.Am. J. Digest. Dis. 2:318, 1957.
Suzuki, K. Contributions to the pathology of liver cirrhosis, especially the statistical pathological report about the dissected cases in the pathological institute of the Kumamoto Medical College.Japan. J. Med. Sci. V. Pathol. 2:1, 1934.
Swisher, W. P., Baker, L. A., andBennett, H. D. Peptic ulcer and Laennec's cirrhosis.Am. J. Digest. Dis. 22:291, 1955.
Smith, H. W.,et al. Intraluminal pressures from the upper gastrointestinal tract: Part II. Correlations with gastroduodenal motor activity in normal subjects and patients with ulcer distress.Gastroenterology 32:1025, 1957.
Zamcheck, N.,et al. The bromsulphalein test in the early diagnosis of liver disease in gross upper gastrointestinal hemorrhage.Gastroenterology 14:343, 1950.
Zamcheck, N.,et al. Early roentgen diagnosis in massive bleeding from the upper gastrointestinal tract: I. Clinical evaluation of safety and reliability of the method in 123 patients.Am. J. Med. 13:713, 1952.
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This investigation was supported in part by a Research Grant (RG 4633) National Institutes of Health, Public Health Service.
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Koide, S.S., Texter, E.C. & Borden, C.W. Performation of peptic ulcer following paracentesis in patients with cirrhosis. Digest Dis Sci 3, 24–37 (1958). https://doi.org/10.1007/BF02231306
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DOI: https://doi.org/10.1007/BF02231306