The American Journal of Digestive Diseases

, Volume 3, Issue 1, pp 12–23 | Cite as

Hexocyclium methosulfate in active duodenal ulcer

Evaluation of a new anticholinergic drug in conventional and long-acting forms, especially its effect on gastric pH as studied in 48-hour analysis
  • Anthony M. Kasich
  • Harry D. Fein

Summary and conclusions

A study of hexocyclium, a new anticholinergic drug, has been reported.

1. After a control period, hexocyclium was administered in both conventional and long-acting forms to 28 patients with active duodenal ulcers. The pH of hourly samples of gastric secretion was determined, and was definitely higher when hexocyclium was administered. The long-acting form of the drug produced a more sustained effect than the conventional form.

2. At present, 57 patients with duodenal ulcer are under active treatment with hexocyclium, and control of their symptoms is satisfactory. Side effects have been minor. No treatment has had to be discontinued, and in only two instances has the dosage been reduced.

3. Hexocyclium is effective for the control of cramps and diarrhea in cases of irritable bowel syndrome.

There is a definite place for a long-acting anticholinergic drug, such as long-acting hexocyclium, in the over-all treatment of peptic ulcer. It is emphasized, however, that anticholinergic medication should not be used in place of other ulcer therapy, but rather as an important adjunct to diet and antacids, especially at night.


Public Health Diarrhea Irritable Bowel Syndrome Peptic Ulcer Active Treatment 
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Copyright information

© Paul B. Hoeber, Inc. 1958

Authors and Affiliations

  • Anthony M. Kasich
    • 1
  • Harry D. Fein
    • 1
  1. 1.New York 21

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