Skip to main content
Log in

Regulation of food intake

  • The Physiology Of Symptoms (II)
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Conclusion

In normal animals and human beings the intake of food is precisely regulated to the level of energy expenditure, thus keeping body stores constant. The mechanisms by which this regulation is accomplished include oropharyngeal, gastrointestinal, blood chemical, tissue metabolic, and other factors. The ultimate integration of the information received from these various sites is accomplished by the central nervous system. Although many parts of the central nervous system participate, several areas in the hypothalamus have been identified which exert profound inhibitory or facilitatory influences on feeding reflexes.

The nature of the defect or defects in regulation which lead to obesity in human subjects is unknown.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Anderson, B., andLarsson, S. Water and food intake and the inhibitory effect of amphetamine on drinking and eating before and after “prefrontal lobotomy” in dogs.Acta physiol. scandinav. 38:29, 1956.

    Google Scholar 

  2. Brobeck, J. R. Neural regulation of food intake.Ann. New York Acad. Sc. 63:44, 1955.

    Google Scholar 

  3. Brobeck, J. R. Neural basis of hunger, appetite, and satiety.Gastroenterology 32:169, 1957.

    PubMed  Google Scholar 

  4. Grossman, M. I. Integration of current views on the regulation of hunger and appetite.Ann. New York Acad. Sc. 63:76, 1955.

    Google Scholar 

  5. Grossman, M. I. Nutrition and nutritional diseases.Ann. Rev. Med. 8:177, 1957.

    PubMed  Google Scholar 

  6. Janowitz, H. D., andHollander, F. The time factor in the adjustment of food intake to varied caloric requirement in the dog: A study of the precision of appetite regulation.Ann. New York Acad. Sc. 63:56, 1955.

    Google Scholar 

  7. Mayer, J. Regulation of energy intake and the body weight: The glucostatic theory and the lipostatic hypothesis.Ann. New York Acad. Sc. 63:15, 1955.

    Google Scholar 

  8. Mayer, J. The physiological basis of obesity and leanness.Nutrition Abstr. & Rev. 25:597, 871, 1955.

    Google Scholar 

  9. Mellinkoff, S. M.,et al. Relationship between serum amino acid concentration and fluctuations in appetite.J. Appl. Physiol. 8:535, 1956.

    PubMed  Google Scholar 

  10. Miller, N. E. Experiments on motivation.Science 126:1271, 1957.

    PubMed  Google Scholar 

  11. Schulman, J. L.,et al. Effect of glucagon on food intake and body weight in man.J. Appl. Physiol. 11:419, 1957.

    PubMed  Google Scholar 

  12. Stunkard, A. J., Van Itallie, T. B., andReis, B. B. The mechanism of satiety: Effect of glucagon on gastric hunger contractions in man.Proc. Soc. Exper. Biol. & Med. 89:258, 1955.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grossman, M.I. Regulation of food intake. Digest Dis Sci 3, 659–668 (1958). https://doi.org/10.1007/BF02231238

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02231238

Keywords

Navigation