Conclusion
In normal animals and human beings the intake of food is precisely regulated to the level of energy expenditure, thus keeping body stores constant. The mechanisms by which this regulation is accomplished include oropharyngeal, gastrointestinal, blood chemical, tissue metabolic, and other factors. The ultimate integration of the information received from these various sites is accomplished by the central nervous system. Although many parts of the central nervous system participate, several areas in the hypothalamus have been identified which exert profound inhibitory or facilitatory influences on feeding reflexes.
The nature of the defect or defects in regulation which lead to obesity in human subjects is unknown.
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Grossman, M.I. Regulation of food intake. Digest Dis Sci 3, 659–668 (1958). https://doi.org/10.1007/BF02231238
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DOI: https://doi.org/10.1007/BF02231238