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Chronic effects of nicotine on gastric secretion in rats with hypothalamic lesions

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Abstract

The gastric secretory response to chronic injections of nicotine (2000 µg base /kg/day for 14 days) was studied in 2-hour pylorus-ligated male Sprague-Dawley rats (256.8±1.3 g). In sham anterior hypothalamic-lesioned animals, nicotine produced an increase in gastric juice volume and in acid and pepsin outputs. After bilateral electrolytic destruction of the anterior hypothalamic area or the rostral portion of the ventromedial nucleus, the response to chronic nicotine administration was abolished. Bilateral electrolytic lesions in the posterior hypothalamus did not block the gastric secretory stimulation produced by nicotine, whereas bilateral abdominal vagotomy did. It is concluded that the gastric secretory stimulation produced by the chronic administration of nicotine is mediated via the anterior hypothalamic area, the ventromedial nucleus in the anterior hypothalamus and the vagus nerves.

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Authors and Affiliations

  1. From the Department of Pharmacology and Experimental Therapeutics, University of California at Los Angeles, 90024, Los Angeles, Calif

    Jeremy H. Thompson MD (Dublin) (FRCPI) & Robert George PhD

Authors
  1. Jeremy H. Thompson MD (Dublin)
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  2. Robert George PhD
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Supported in part by a grant from the American Medical Association Education and Research Foundation.

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Thompson, J.H., George, R. Chronic effects of nicotine on gastric secretion in rats with hypothalamic lesions. Digest Dis Sci 17, 513–518 (1972). https://doi.org/10.1007/BF02231206

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