The American Journal of Digestive Diseases

, Volume 4, Issue 4, pp 276–281 | Cite as

The influence of probanthine upon the gastric secretion of HCl and pepsin in patients with peptic ulcers

  • R. Ronský
  • I. Skaĺa


1. The influence on the basal gastric secretion of 50 mg. of Probanthine, administered orally 30 minutes before intubation and after histamine, was observed in 14 patients.

2. The average concentration of pepsin fell by 39 per cent in the basal secretion, and by 37 per cent after histamine (P<0.01).

3. The total output of pepsin fell by 40 per cent in the basal secretion (P<0.01), and by 54 per cent in the secretion after histamine (P<0.001).

4. The quantity of the gastric juice fell by 43 per cent after the administration of histamine (P<0.001), while the decrease of the basal secretion was not significant (P>0.05).

5. Probanthine did not influence the acidity of the gastric juice substantially. A decrease of 6 to 9 per cent is not considered significant.


Public Health Acidity Histamine Peptic Ulcer Average Concentration 
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Copyright information

© Paul B. Hoeber, Inc. 1959

Authors and Affiliations

  • R. Ronský
    • 1
  • I. Skaĺa
    • 1
  1. 1.From the Fourth Medical Clinic of Charles UniversityPragueCzechoslovakia

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