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The American Journal of Digestive Diseases

, Volume 5, Issue 8, pp 739–750 | Cite as

Whipple's disease

Report of a case
  • Helen D. Van Vactor
  • Bernard D. Rosenak
Case Reports

Summary

A typical case of Whipple's disease is reported, substantiated by histopathologic study. Treatment with steroids has been used with good results. A prolonged clinical remission has occurred, although persistance of pathologic changes in the small intestine has been demonstrated. This disease is a generalized one with polyserositis and malabsorption, the etiology of which is unknown. A genetic factor has been suggested, with the presence of a basic defect in intestinal cell absorption. That it may represent a general sensitivity reaction with inflammation, is possible. It may be amenable to steroid therapy.

Keywords

Public Health Steroid Small Intestine Genetic Factor Pathologic Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bassler, A. Two cases of Whipple's disease.Am. J. Digest. Dis. 21:178, 1954.Google Scholar
  2. 2.
    Case Records of The Massachusetts General Hospital (Case 43131).New England J. Med. 256:612, 1957.Google Scholar
  3. 3.
    Crane, J., andAguilar, M. J. Obliterative lymphangitis of the mesentery in Whipple's disease.Gastroenterology 32:513, 1957.PubMedGoogle Scholar
  4. 4.
    Douglas, F. C. Intestinal lipodystrophy (Whipple's disease).Texas J. Med. 51:648, 1955.PubMedGoogle Scholar
  5. 5.
    Eyler, W. R., andDoub, H. P. Extraintestinal roentgen manifestations of intestinal lipodystrophy.J.A.M.A. 160:534, 1956.Google Scholar
  6. 6.
    Gross, J. B., Wollaeger, E. E., Sauer, W. G., Huizenga, K. A., Dahlin, D. C., andPower, M. H. Whipple's disease.Gastroenterology 36:65, 1959.PubMedGoogle Scholar
  7. 7.
    Hunter, R. C., Jr., andWard, J. R. Intestinal lipodystrophy (Whipple's disease) treated with ACTH and corticosteroids.Am. J. Digest. Dis. 2:388, 1957.PubMedGoogle Scholar
  8. 8.
    Lepore, M. J. Whipple's intestinal lipodystrophy.Am. J. Med. 17:160, 1954.PubMedGoogle Scholar
  9. 9.
    Marshak, R., andEliasoph, J. Roentgen findings in malabsorption syndromes.M. Clin. North America 41:1565, 1957.Google Scholar
  10. 10.
    Oren, B. G., andFleming, R. M. A possible case of Whipple's disease.Gastroenterology 29:120, 1954.Google Scholar
  11. 11.
    Puite, R. H., andTesluk, H. Whipple's disease.Am. J. Med. 19:383, 1955.PubMedGoogle Scholar
  12. 12.
    Radding, J., andFiese, M. Whipple's disease (intestinal lipodystrophy): Review of the literature and report of case successfully treated with adrenocorticotrophin (ACTH) and cortisone.Ann. Int. Med. 41:1066, 1954.PubMedGoogle Scholar
  13. 13.
    Scott, P. W., andHosie, R. T. Whipple's disease.Arch. Int. Med. 100:280, 1957.Google Scholar
  14. 14.
    Schaffner, F., andScherbel, A. L. Whipple's disease. Glycoprotein, lipoprotein and other biochemical studies before and after successful cortisone treatment.Gastroenterology 29:109, 1955.PubMedGoogle Scholar
  15. 15.
    Sieracki, J. C. Whipple's disease—observation on systemic involvement: I. Cytologic observations.A.M.A. Arch. Path. 66:464, 1958.PubMedGoogle Scholar
  16. 16.
    Wang, C. I., Janowitz, H. D., andAdlersburg, D. Intestinal lipodystrophy (Whipple's disease) amenable to corticosteroid therapy.Gastroenterology 30:475, 1956.PubMedGoogle Scholar

Copyright information

© Paul B. Hoeber, Inc. 1960

Authors and Affiliations

  • Helen D. Van Vactor
    • 1
  • Bernard D. Rosenak
    • 1
  1. 1.From the Department of MedicineIndiana University School of MedicineIndianapolis

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