The American Journal of Digestive Diseases

, Volume 6, Issue 6, pp 554–569 | Cite as

Precancerous disease of the gastrointestinal tract

  • Charles A. Flood
Current Gastroenterology
  • 39 Downloads

Summary

The gastrointestinal disorders regarded as potentially premalignant are the benign epithelial growths and the inflammatory and degenerative diseases of the mucous membrane. The majority of large-bowel carcinomata appear to start as adenomatous polyps. Chronic ulcerative colitis also appears to predispose to development of malignancy.

Probably only a small proportion of gastric carcinomata are preceded by adenomatous polyps or benign gastric ulcer. Chronic inflammatory gastritis or gastric atrophy may precede the development of carcinoma in many cases.

Hereditary factors play a role in the pathogenesis of colonic polyps, and there is evidence suggesting that heredity may at times predetermine gastric atrophy. Other etiologic factors in the development of carcinomatous precursors in the gastrointestinal tract remain obscure.

Keywords

Gastrointestinal Tract Ulcerative Colitis Gastritis Gastric Carcinoma Gastric Ulcer 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Coller, F. A., andBerry, R. L. Cancer of the colon.J.A.M.A. 135:1061, 1947.Google Scholar
  2. 2.
    Miller, C. J., Day, E., andL'Esperance, E. S. Value of proctoscopy as routine examination in preventing deaths from cancer of large bowel.New York J. Med. 50:2023, 1950.PubMedGoogle Scholar
  3. 3.
    Grinnell, R. S., andLane, N. Benign and malignant adenomatous polyps and papillary adenomas of the colon and rectum. An analysis of 1856 tumors in 1335 patients.Surg., Gynec. & Obst. 106:519, 1958.Google Scholar
  4. 4.
    Sauer, W. G. Polyps of the colon and rectum.Gastroenterology 34:306, 1958.PubMedGoogle Scholar
  5. 5.
    Dukes, C. E. In Jones, F. A. (Ed.)Modern Trends in Gastroenterology, Second Series. New York, Hoeber, 1958.Google Scholar
  6. 6.
    Sunderland, D. A., andBinkley, G. E. Papillary adenomas of the large intestine: A clinical and morphological study of 48 cases.Cancer 1:184, 1948.Google Scholar
  7. 7.
    Lloyd-Davis, O. V., andDukes, C. E., In Jones, F. A. (Ed.)Modern Trends in Gastroenterology, First Series. New York, Hoeber, 1952, p. 638.Google Scholar
  8. 8.
    Jackman, R. J., Bargen, J. A., andHelmhoetz, H. F. Life histories of 95 children with ulcerative colitis.Am. J. Dis. Child. 59:459, 1940.Google Scholar
  9. 9.
    Bacon, H. E. Ulcerative Colitis. Philadelphia, Lippincott, 1958.Google Scholar
  10. 10.
    Goldgraber, M. B., Humphreys, E. M., Kirsner, J. B., andPalmer, W. C. Carcinoma in ulcerative colitis: a clinical-pathologic study. II. Statistical analysis.Gastroenterology 34:809, 1958.PubMedGoogle Scholar
  11. 11.
    Hitchcock, C. R., Sullivan, W. A., andWangensteen, O. H. The value of achlorhydria as a screening test of gastric cancer.Gastroenterology 29:621, 1955.PubMedGoogle Scholar
  12. 12.
    Comfort, M. W., Kelsey, M. D., andBerkson, J. Gastric acidity before and after development of carcinoma of the stomach.J. Nat. Cancer Inst. 7:367, 1947.Google Scholar
  13. 13.
    Konjetzny, G. E. Der Magenkrebs. Stuttgart, Enke, 1936.Google Scholar
  14. 14.
    Mosbech, J., andVidebaek, A. Mortality from and risk of gastric carcinoma among patients with pernicious anemia.Brit. M. J. 2:390, 1950.PubMedGoogle Scholar
  15. 15.
    Schell, R. F., Dockerty, M. B., andComfort, M. W. Carcinoma of the stomach associated with pernicious anemia.Surg. Gynec. & Obst. 98:710, 1954.Google Scholar
  16. 16.
    Flood, C. A. Carcinoma of the stomach.Ann. Int. Med. 48:919, 1958.PubMedGoogle Scholar
  17. 17.
    Flood, C. A., andHennig, G. C. Recurrence in gastric ulcer under medical management.Gastroenterology 14:280, 1950.PubMedGoogle Scholar
  18. 18.
    Carey, J. B., andHay, L. J. Symposium on gastric neoplasms. Gastric polyps.Gastroenterology 14:280, 1950.PubMedGoogle Scholar
  19. 19.
    Spriggs, E. J., andMarxfr, O. Polyps of the stomach and polypoid gastritis.Quart. J. Med. 12:1, 1943.Google Scholar
  20. 20.
    Niemetz, D., andWharton, G. K. Benign gastric polyps.Ann. Int. Med. 42:339, 1955.PubMedGoogle Scholar
  21. 21.
    Berg, J. Histological aspects of the relation between gastric adenomatous polyps and gastric cancer.Cancer 11:1149, 1958.PubMedGoogle Scholar
  22. 22.
    Wangensteen, O. H. Cancer of the Esophagus and the Stomach. New York, American Cancer Society, Inc., 1951.Google Scholar
  23. 23.
    Brunn, H., andPeari, F. Diffuse gastric polyposis.Surg., Gynec., & Obst. 43:559, 1926.Google Scholar
  24. 24.
    Gardner, E. J., andRichard, R. C. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis.Am. J. Human Genet. 5:137, 1953.Google Scholar
  25. 25.
    Woolf, C. M. A genetic study of carcinoma of the large intestine.Am. J. Human Genet. 10:42, 1947.Google Scholar
  26. 26.
    Mosbech, J. Heredity in Pernicious Anemia: A Proband Study of the Heredity and the Relationship to Cancer of the Stomach. Copenhagen, Munksgaard, 1953.Google Scholar
  27. 27.
    Joske, R. A., Finckh, E. S., andWood, I. J. Gastric biopsy: A study of 1000 consecutive successful gastric biopsies.Quart. J. Med. 24:277, 1955.Google Scholar

Copyright information

© Paul B. Hoeber, Inc., Medical Division of Harper & Brothers 1961

Authors and Affiliations

  • Charles A. Flood
    • 1
  1. 1.From the Department of Medicine, College of Physicians and SurgeonsColumbia University and The Presbyterian HospitalNew York

Personalised recommendations