Skip to main content
SpringerLink
Log in

Action of aminoguanidine on the stomach of pylorus-ligated rats

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

The action of aminoguanidine on gastric secretion was studied in rats with 4-hour pylorus ligation. Aminoguanidine produced only a moderate elevation in gastric secretion, with a great increase in the number of ulcers, ecchymoses in the glandular stomach, and histologic changes throughout the glandular mucosa.

Histamine administration increased the amount of tissue pepsinogen but caused no changes in the other values. Aminoguanidine does not sensitize the rat to the dose of histamine used.

The administration of both drugs simultaneously did not change the values, as compared with the controls, but again there was an increase in pepsinogen and a significant number of ulcers in the squamous stomach, with marked diminution of lesions in the glandular portion.

The results are analyzed, and the location of the lesions, as well as the histologic findings in relation to the histaminolytic activity of each portion of the stomach of the rat studied, is discussed. The possible role of enzymatic inhibition is examined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Angelakos, T., andLoew, E. R. Histamine toxicity in mice and rats following treatment with histaminase inhibitors.J. Pharmacol. & Exper. Therap. 119:444, 1957.

    Google Scholar 

  2. Anson, M. L. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin.J. Gen. Physiol. 22:79, 1938.

    Article  Google Scholar 

  3. Friedman, M. H. F. Histamine ineffective in the rat as a gastric stimulant.Proc. Soc. Exper. Biol. & Med. 54:42, 1943.

    Google Scholar 

  4. Ivy, A. C., Lin, T. M., Ivy, E. K., andKarvinen, E. Effect of histaminase inhibitors on gastric secretion.Am. J. Physiol. 186:239, 1956.

    PubMed  Google Scholar 

  5. Ivy, A. C., andLiepins, K. V. Effect of derivatives and inhibitors of histamine metabolism on gastric secretion.Am. J. Physiol. 195:521, 1958.

    PubMed  Google Scholar 

  6. Ivy, A. C., andLiepins, K. W. Effect of aminoguanidine on the gastric secretory response to 3-beta-aminoethyl-1,2,4, triazole. XXI International Congress of Physiological Sciences (Abstract). Buenos Aires, 1959, p. 135.

  7. Jones, T. W., andHarkins, H. N. Evaluation of mechanisms involved in gastric acid secretion of pylorus-ligated rats.Gastroenterology 35:309, 1958.

    PubMed  Google Scholar 

  8. Kobayashi, Y., andIvy, A. C. Histamine metabolizing activity of the stomach and intestine of the rat.Am. J. Physiol. 196:835, 1959.

    PubMed  Google Scholar 

  9. Kahlson, G. E., Rosengen, J. H., andWestling, H. Increased formation of histamine in the pregnant rat.J. Physiol. 143:91, 1958.

    PubMed  Google Scholar 

  10. Komarov, V., Shay, H., Rayport, M., andFels, S. Some observations on gastric secretion in normal rats.Gastroenterology 3:406, 1944.

    Google Scholar 

  11. Liepins, K. V., Ivy, A. C., andSuzuki, R. Effect of certain histaminase inhibitors on gastric secretion.Am. J. Physiol. 195:209, 1958.

    PubMed  Google Scholar 

  12. Liepins, K. V. Stimulant effect of subcutaneous aminoguanidine (AG) and iproniazid (IPN) (histaminase inhibitors) on the gastric secretory response to a meal.Fed. Proc. 17:97, 1958.

    Google Scholar 

  13. Lin, T. M., Ivy, A. C., Karvinen, E., andIvy, E. K. Effect of an histaminase inhibitor (aminoguanidine) on the gastric secretory response to exogenous histamine.Am. J. Physiol. 186:231, 1956.

    PubMed  Google Scholar 

  14. Lin, T. M., Alphin, R. S., Henderson, F. G., andVhen, K. K. Effect of histamine derivatives and histaminase inhibitors on gastric secretion in dogs. XXI International Congress of Physiological Sciences (Abstract). Buenos Aires, 1959, p. 164.

  15. Lozzio, B. B., Gagliardi, O. P., Biempica, L., andRoyer, M. Effects of pregnancy on gastric secretion in rats.Gastroenterology. In press.

  16. Pfeiffer, C. C., Killan, K. F., Jenney, E. H., andMarshall, W. H. Cited by Angelakos and Loew.J. Pharmacol. & Exper. Therap. 119:444, 1957.

    Google Scholar 

  17. Roberts, M., andRobson, J. M. The histaminase content of the rat uterus and its relation to the decidua.J. Physiol. 119:286, 1953.

    PubMed  Google Scholar 

  18. Roberts, M. The effect of a histaminase-inhibitor (aminoguanidine) on pregnancy in the rat.J. Endocrinol. 11:338, 1954.

    PubMed  Google Scholar 

  19. Schayer, R. W., andSmiley, R. L. Binding and release of radioactive histamine in intact rats.Am. J. Physiol. 177:401, 1954.

    PubMed  Google Scholar 

  20. Schayer, R. W., Wu, K. Y. T., andSmiley, R. L. Sources of urinary histamine in the rat.Am. J. Physiol. 179:481, 1954.

    PubMed  Google Scholar 

  21. Schayer, R. W. The origin of histamine in the body. Symposium on Histamine, CIBA Foundation. London, Churchill, 1956, p. 298.

    Google Scholar 

  22. Schayer, R. W. The origin and fate of histamine in the body. Symposium on Histamine, CIBA Foundation. London, Churchill, 1956, p. 183.

    Google Scholar 

  23. Stern, P. Interpretation of the inefficacy of antihistaminics upon the secretion of gastric juice.J. Allergy 26:268, 1955.

    Article  PubMed  Google Scholar 

  24. Schuler, W. Zur Hemmung der Diamimoxidase (histaminase)Experientia 8:230, 1952.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From Instituto de Gastroenterologia, Institutos Nacionales de la Salud, Ramos Mejia, Buenos Aires, Argentina

    B. B. Lozzio M.D., L. Biempica M.D., M. Royer M.D. & S. Gorodisch M.D.

Authors
  1. B. B. Lozzio M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Biempica M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Royer M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Gorodisch M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The authors thank Misses Blanca Estupiñan, Myrna Lozzio, and Maria Rodriguez for their technical assistance.

Fellow, Argentine National Research Council.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lozzio, B.B., Biempica, L., Royer, M. et al. Action of aminoguanidine on the stomach of pylorus-ligated rats. Digest Dis Sci 6, 534–545 (1961). https://doi.org/10.1007/BF02231073

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02231073

Keywords

Search

Navigation