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The Italian Journal of Neurological Sciences

, Volume 16, Issue 8, pp 589–594 | Cite as

Breathing during sleep in myasthenia gravis

  • Manni R. 
  • Piccolo G. 
  • Sartori I. 
  • Castelnovo G. 
  • Raiola E. 
  • Lombardi M. 
  • Cerveri I. 
  • Fanfulla F. 
  • Tartara A. 
Original Articles

Abstract

The aim of this study was to assess breathing patterns during sleep in patients with generalized mild myasthenia gravis. Fourteen patients (13 F; 1M, age range 20–40 years) in a stable clinical and functional state underwent a sleep questionnaire, baseline respiratory function tests and standard nocturnal polysomnography.

All of the patients had normal daytime blood-gas values, except one who showed mild hypoxemia. No patient complained of disturbed sleep; six patients reported snoring. In five patients nocturnal polysomnoraphy showed the occurrence of short and infrequent central apneas mainly during REM sleep, together with a drop in HbSaO2 levels of more than 5% of the baseline wakefulness value.

Our data indicate that, in patients with mild generalized MG in a stable functional state, breathing pattern instability during sleep is infrequent and, when it occurs, is mild and mainly related to REM sleep.

Key Words

Myasthenia Gravis Sleep Breathing 

Sommario

Scopo del presente lavoro è la valutazione dei pattern respiratori durante il sonno notturno in pazienti affetti da miastenia generalizzata, di grado lieve moderato, in fase di compenso clinico ed emogasanalitico. È stato condotto uno studio clinico e di polisonnografia notturna standard in 14 soggetti miastenici (13 F, 1 M; 20–40 anni di età) senza altri fattori di rischio per lo sviluppo di disordini respiratori sonno relati eccetto il proprio deficit neuromuscolare. Nessun soggetto riferiva sintomi suggestivi di disturbi respiratori sonno relati, eccetto russamento (riferito da 6 pazienti). In 5 soggetti sono state documentate, alla polisonnografia notturna, sporadiche apnee, di tipo non ostruttivo, prevalentemente REM relate, con desaturazioni di HbSaO2 superiori al 5% del valore imedio basale in veglia, raramente comunque con desaturazioni al di sotto del 90%. Globalmente i dati indicano che in soggetti miastenici con grado lieve di malattia, in fase di compenso e senza altri fattori di rischio, la respirazione notturna rimane relativamente ben compensata.

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Copyright information

© Masson Italia Periodici S.r.l. 1995

Authors and Affiliations

  • Manni R. 
    • 1
  • Piccolo G. 
    • 1
  • Sartori I. 
    • 1
  • Castelnovo G. 
    • 1
  • Raiola E. 
    • 1
  • Lombardi M. 
    • 1
  • Cerveri I. 
    • 2
  • Fanfulla F. 
    • 2
  • Tartara A. 
    • 1
  1. 1.Istituto Neurologico “C. Mondino”Università di PaviaPaviaItaly
  2. 2.Istituto di Malattie RespiratorieUniversità di PaviaPaviaItaly

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