The Italian Journal of Neurological Sciences

, Volume 7, Issue 1, pp 63–69 | Cite as

Motor and psychomotor functions in amyotrophic lateral sclerosis evaluated by tests of motor ability

  • Poloni M. 
  • Mazzini L. 
  • Ceroni M. 
  • Tosca P. 
  • Bezzi G. 
Original Articles


18 patients with typical sporadic Amyotrophic Lateral Sclerosis (ALS) were investigated by the Motor Accuracy and Speed Test (MAST) and 18 healthy age-and-sex-matched volunteers, acted as controls. All performed each of the five tests 10 times with both the right and the left hands and repeated the experiment after one week by the same procedure. Motor performances were better in the controls than in the ALS patients only in the first three tasks. At retest, one week later, the controls generally improved while ALS patients did not. The mean percentages of changes showed a statistically significant difference in the fifth task. Analysis of the results suggests the possibility that, among the other mechanisms, a disturbance of motor learning ability could be operating in ALS patients.


Motor ability tests learning amyotrophic lateral sclerosis 


18 pazienti con Sclerosi Laterale Amiotrofica e 18 volontari sani di uguale sesso ed età sono stati sottoposti al “Motor Accuracy and Speed test” (MAST). Ogni soggetto ha eseguito ciascuna delle 5 prove 10 volte, sia con la mano destra che con quella sinistra; l'esperimento veniva ripetuto, con le stesse modalità, dopo una settimana. L'esecuzione era migliore nei controlli, ma solo per le prime tre prove. Al controllo, dopo una settimana, soltanto i controlli erano capaci di migliorare la propria prestazione e nella quinta prova si notava una differenza significativa rispetto ai pazienti con Sclerosi Laterale Amiotrofica.

L'analisi dei risultati suggerisce la possibilità che, oltre agli altri meccanismi, possa avere importanza anche una difficoltà di apprendimento motorio nella Sclerosi Laterale Amiotrofica.


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  1. [1]
    Appel S.H.:A unifying hypothesis for the cause of Amyotrophic Lateral Sclerosis, Parkinsonism and Alzheimer's disease. Ann. Neurol. 10, 499–505, 1981.CrossRefPubMedGoogle Scholar
  2. [2]
    Averback P., Crocker P.:Regular involvement of Clarke's Nucleus in sporadic Amyotrophic Lateral Sclerosis. Arch. Neurol. 39, 155–156, 1982.PubMedGoogle Scholar
  3. [3]
    Belendiuk K., Belendiuk G.W., Freedman D.K., Antel J.P.:Neurotransmitter abnormalities in patients with motor neuron disease. Arch. Neurol. 38, 415–417, 1981.PubMedGoogle Scholar
  4. [4]
    Bernstein L.P., Antel S.P.:Motor Neuron Disease: decremental responses to repetitive nerve stimulation. Neurology 31, 202–205, 1981.PubMedGoogle Scholar
  5. [5]
    Briggs P.F., Tellegen A.:Development of the Manual Accuracy and Speed Test (MAST). Perceptual and Motor Skills 32, 923–943, 1971.PubMedGoogle Scholar
  6. [6]
    Brown W.A., Muller P.S.:Psychological function in individuals with ALS. Psychosom. Med. 32, 141–152, 1970.PubMedGoogle Scholar
  7. [7]
    Brownell B., Oppenheimer D.R., Hughes J.T.:The central nervous system in motor neuron disease. Neurol. Psych. 33,338–357, 1970.Google Scholar
  8. [8]
    Brody S.A., Chase T.N., Gordon E.K.:Depressed monoamine catabolite levels in cerebrospinal fluid of patients with parkinsonian dementia of Guam. N. Engl. J. Med. 282,947–950, 1970.PubMedGoogle Scholar
  9. [9]
    Cosi V., Poloni M., Mazzini L., Callieco R.:Somatosensory evoked potentials in Amyotrophic Lateral Sclerosis. J. Neurol. Neurosurg. Psych. 47,857–861, 1984.Google Scholar
  10. [10]
    De Queiroz, S., Nucci A., Pellegrini Filho A.:Motor neuron disease with neurofibrillary tangles in a brasilian woman. J. Neurol. Sci. 33, 21–29, 1977.CrossRefPubMedGoogle Scholar
  11. [11]
    Denys E.H., Norris F.H.:Amyotrophic Lateral Sclerosis: impairment of neuromuscular transmission. Arch. Neurol. 36,202–205, 1979.PubMedGoogle Scholar
  12. [12]
    Emery A.E.H., Holloway S.:Familial motor neuron diseases. In Advances in Neurology, Vol. 36. Ed.: Rowland L.P., Raven Press, New York, 139–148, 1982.Google Scholar
  13. [13]
    Fleishman E.A.:Psychomotor selection test: research and application in the United States Air Force. Personnel Psychol. 9, 449–468, 1956.Google Scholar
  14. [14]
    Fogel B., Funkenstein H.H.:Dysgraphia in Amyotrophic Lateral Sclerosis. Neurology 29, 572, 1979.Google Scholar
  15. [15]
    Gajdusek D.L., Salazar A.M.:Amyotrophic Lateral Sclerosis and parkinsonian syndromes in high incidence among the Auyon Jokai people of West New Guinea. Neurology 32, 107–126, 1982.PubMedGoogle Scholar
  16. [16]
    Hammer R.P., Tomiyasu U., Scheibel A.B.:Degeneration of the human Betz cells due to amyotrophic Lateral Sclerosis. Exp. Neurol. 63, 336–346, 1979.CrossRefPubMedGoogle Scholar
  17. [17]
    Hirano A., Arumugasamy N., Zimmermann H.M.:Amyotrophic Lateral Sclerosis. A comparison of Guam and classical cases. Arch. Neurol. 16, 357–363, 1967.PubMedGoogle Scholar
  18. [18]
    Hirano A., Kurland L.T., Sayre G.P.:Familial Amyotrophic Lateral Sclerosis: a subgroup characterized by posterior and spino-cerebellar tract involvement and by ialine inclusion in the anterior horn cells. Arch. Neurol. 16, 232–243, 1967.PubMedGoogle Scholar
  19. [19]
    Hudson A.J.:Amyotrophic Lateral Sclerosis and its association with dementia, parkinsonism and other neurological disorders: a review. Brain 104, 217–247, 1981.PubMedGoogle Scholar
  20. [20]
    Jacob H.:Muscular twitchings in Alzheimer disease. CIBA foundation Symposium on Alzheimer's Disease. 75–93, 1970.Google Scholar
  21. [21]
    Kurland L.T., Molgaard C.A.:Guamanian ALS: hereditary or acquired? In Advances in Neurology. Vol. 36, Ed.: Rowland L.P., Raven Press, New York, 165–172, 1982.Google Scholar
  22. [22]
    McComas A.J., Upton A.R.M., Sica R.E.P.:Motor neurone disease and aging. Lancet, 2, 1477–1480, 1973.CrossRefPubMedGoogle Scholar
  23. [23]
    Mendell J.R., Chase T.N., Engel W.K.:Amyotrophic Lateral Sclorosis: a study of central monoamine metabolism and therapeutic trial of levodopa. Arch. Neurol. 25, 320–325, 1971.PubMedGoogle Scholar
  24. [24]
    Munsat T.L., Hedlund W., Felmus M., Cooper C., Gabbai A.:Clinical clues to the cause of amyotrophic Lateral Sclerosis. In Neuromuscular Diseases, Ed. Serratrice G., Cros D., Desnuelle C., Gastaut J.L., Pelissier J.F., Pouget J., Schiano A., Raven Press, New York, 329–333, 1984.Google Scholar
  25. [25]
    Paula Barbosa M.M.:Dendritic degeneration and regrowth in the cerebral cortex of patients with Alzheimer's Disease. J. Neurol. Sci. 45, 129–134, 1980.CrossRefPubMedGoogle Scholar
  26. [26]
    Peters P.K., Swenton M.W., Mulder A.W.:Is there a characteristic personality profile in ALS? A Minnesota Multiphasic Personality Inventory Study. Arch. Neurol. 35, 321–322, 1978.PubMedGoogle Scholar
  27. [27]
    Poloni M., Mascherpa C., Faggi L., Rognoni F., Gozzoli L.:Cerebral Atrophy in motor neuron disease evaluated by Computerized Tomography. J. Neurol. Neurosurg. Psych. 45, 1102–1105, 1982.Google Scholar
  28. [28]
    Rosernberg R.N.:Amyotrophy in multisystem genetic disease. In Advances in Neurology, Vol. 36, Ed.: Rowland L.P.; Raven Press, New York, 149–158, 1982.Google Scholar
  29. [29]
    Smith B.H., Arnason B.:Pathology of neurontarget cell interactions. Neurosci. Res. Progr. Bull. 14, 360–366, 1977.Google Scholar
  30. [30]
    Thomas M., Ballantyne J.P., Hansen S., Weir A.I., Doyle D.:Anterior horn cell dysfunction in Alzheimer's disease. J. Neurol. Neurosurg. Psych. 45, 378–381, 1982.Google Scholar
  31. [31]
    Tyler H.R.:Nonfamilial amyotrophy with dementia or multisystem degeneration and other neurological disorders. In Advances in Neurology, Vol. 36, Ed. Rowalnd L.P., Raven Press, New York, 173–180, 1982.Google Scholar
  32. [32]
    Ziegler L.H.:Psychotic and emotional phenomena associated with Amyotrophic Lateral Sclerosis. Arch. Neurol. Psych. 24, 930–936, 1930.Google Scholar

Copyright information

© Masson Italia Periodici S.r.l. 1986

Authors and Affiliations

  • Poloni M. 
    • 2
  • Mazzini L. 
    • 2
  • Ceroni M. 
    • 1
  • Tosca P. 
    • 1
  • Bezzi G. 
    • 1
  1. 1.Clinica NeurologicaUniversità di PaviaPaviaItaly
  2. 2.Clinica Neurologica I Istituto di Scienze BiomedicheOspedale San PaoloMilano

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