Skip to main content
Log in

Primary antiphospholipid syndrome associated with mesenteric inflammatory veno-occlusive disease

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript


We describe a 24-year old Caucasian man with gangrene of small bowels and intestinal resection due to mesenteric inflammatory veno-occlusive disease (MIVOD) who later developed deep vein thrombosis in his left leg. He had no clinical evidence of an underlying symptomatic connective tissue disease or Behçet's disease. An IgG anticardiolipin antibody titre above 60 GPL unit/mL and thrombocytopenia confirmed the diagnosis of primary antiphospholipid syndrome (APS). This is the first known case of APS associated with MIVOD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Hughes, G.R.V. The antiphospholipid syndrome: ten years on. Lancet 1993, 342, 341–352.

    Article  PubMed  Google Scholar 

  2. Lie, J.T. Vasculitis in the antiphospholipid syndrome: culprit or consort (editorial). J Rheumatol 1994, 21, 397–399.

    PubMed  Google Scholar 

  3. Praderio, L., D'Angelo, A., Taccagni, G., et al. Association of lupus anticoagulant with polyarteritis nodosa: report of a case. Haematologica 1990, 75, 387–390.

    PubMed  Google Scholar 

  4. Cid, M.C., Cervera, R., Font, J., et al. Late thrombotic events in patients with temporal arteritis and anticardiolipin antibodies. Clin Exp Rheumatol 1990, 8, 359–363.

    PubMed  Google Scholar 

  5. Norden, D.K., Ostrov, B.E., Shafritz, A.B., von Feldt, J.M. Vasculitis associated with antiphospholipid syndrome. Semin Arthritis Rheum 1995, 24, 273–281.

    Article  PubMed  Google Scholar 

  6. Flaherty, M.J., Lie, J.T., Haggitt, R.C. Mesenteric inflammatory veno-occlusive disease. A seldom recognized cause of intestinal ischemia. Am J Surg Pathol 1994, 18, 779–784.

    PubMed  Google Scholar 

  7. Saraga, E.P., Costa, J. Idiopathic entero-colic lymphocytic phlebitis: A cause of ischemic intestinal necrosis. Am J Surg Pathol 1989, 13, 303–308.

    PubMed  Google Scholar 

  8. Boley, S.J., Kaleya, R.N., Brandt, L.J. Mesenteric venous thrombosis. Surg Clin North Am 1992, 72, 183–201.

    PubMed  Google Scholar 

  9. Jensen, C.B., Smith, G.A. Clinical study of 51 cases of mesenteric infarction. Surgery 1956, 40, 930–933.

    PubMed  Google Scholar 

  10. Naitove, A., Weismann, R.E. Primary mesenteric venous thrombosis. Ann Surg 1965, 161, 516–523.

    PubMed  Google Scholar 

  11. Kitchens, C.S. Evolution of our understanding of the pathophysiology of primary mesenteric venous thrombosis. Am J Surg 1992, 163, 346–348.

    Article  PubMed  Google Scholar 

  12. Gruenberg, J.C., Smallridge, R.C., Rosenberg, R.D. Inherited antithrombin-III deficiency causing mesenteric venous infarction: a new clinical entity. Ann Surg 1975, 181, 791–794.

    PubMed  Google Scholar 

  13. Green, D., Ganger, D.R., Blei, A.T. Protein C deficiency in splanchnic venous thrombosis. Am J Med 1987, 82, 1171–1174.

    Article  PubMed  Google Scholar 

  14. Porter, J., Vesely, M., Jane, S., Stebbing, M.A. Mesenteric venous thrombosis with protein S deficiency (letter). Am J Gastroenterol 1993, 88, 2143.

    Google Scholar 

  15. North, J.P., Wollenman, O.J. Jr. Venous mesenteric occlusion in the course of migrating thrombophlebitis. Surg Gynecol Obstet 1952, 95, 665–671.

    PubMed  Google Scholar 

  16. Britton, B.J., Royle, G. Mesenteric venous thrombosis (letter). Br J Surg 1982, 69, 117–118.

    PubMed  Google Scholar 

  17. Rocca, P.V., Siegel, L.B., Cupps, T.R. The concomittant expression of vasculitis and coagulopathy: synergy for marked tissue ischemia. J Rheumatol 1994, 21, 556–560.

    PubMed  Google Scholar 

  18. Asherson, R.A., Morgan, S.A., Harris, E.N., et al. Arterial occlusion causing large bowel infarction-a reflection of clotting diathesis in SLE. Clin Rheumatol 1986, 5, 102–106.

    Article  PubMed  Google Scholar 

  19. Jona, J., Cummins, G.M., Head, H.B., Govostis, M.C. Recurrent primary mesenteric venous thrombosis. JAMA 1974, 227, 1033–1035.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Gül, A., Inanç, M., Öcal, L. et al. Primary antiphospholipid syndrome associated with mesenteric inflammatory veno-occlusive disease. Clin Rheumatol 15, 207–210 (1996).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

Key words