Summary
A 23-year-old female with systemic lupus erythematosus is reported. The clinical features included fever, shortness of breath, lymphadenopathies, hepatosplenomegaly, pleural and pericardial fluids, ANA and Anti-DNA positivity. Pleural biopsy was false positive for malignancy on two occasions. High CA125 levels were detected in both serum and pleural fluid. Following prednisolone treatment, clinical and laboratory findings returned to normal.
Similar content being viewed by others
References
Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N., Winchester, R.J. 1982 reviewed criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1271–1277.
Miller, L.R., Greenberg, D., Mclarty, J.W. Lupus lung. Chest 1985, 88, 265–269.
Pines, A., Kaplinsky, N., Olchovsky, D., Ozeman, J., Frankl, O. Pleura-pulmonary manifestations of systemic lupus erythematosus: clinical features of its subgroups prognostic and therapeutic implications. Chest 1985, 88, 129–135.
Lewis, R.B., Castor, C.W., Knisley, R.E., Bole, G.G. Frequency of neoplasia in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1976, 19, 1256–1260.
Cash, J.M., Klippel, J.H. Rheumatic diseases and cancer. Clin Exp Rheum 1991, 9, 109–112.
Nance, K.V., Shermer, R.W., Askin, F.B. Diagnostic efficacy of pleural biopsy as compared with that of pleural fluid examination. Modern Pathology 1991, 4, 320–324.
Hoff, D.D.V., Livolsi, V. Diagnostic reliability of needle biopsy of the pleura. Am J Clin Pathol 1975, 64, 200–203.
Poe, R.H., Israel, R.H., Utell, M.J., Hall, W.J., Greenblatt, D.W., Kallay, M.C. Sensitivity, specificity and predictive values of closed pleural biopsy. Arch Intern Med 1984, 144, 325–328.
Kelley, S., McGarry, P., Hutson, Y. Atypical cells in pleural fluid of systemic lupus erythematosus. Acta Cytol 1971, 15, 357–362.
Bast, R.C., Klug, T.L., John, E.S., Jenison, E., Nloff, J.M., Lazarus, H. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 1983, 309, 883–887.
Macri, C.I., Vasilev, S.A. Highly elevated CA125 and tubo-ovarian abscess mimicking ovarian carcinoma. Gynecol Obstet Invest 1994, 37, 143–144.
Ye, C., Ito, K., Komatsu, Y., Takagi, H. Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. Gynecol Oncol 1994, 52, 267–271.
Penna, L., Manyonda, I., Amias, A. Intra-abdominal miliary tuberculosis presenting as disseminated ovarian carcinoma with ascites and raised CA125. Br J Obstet Gynaecol 1993, 100, 1051–1053.
Daoud, E., Bodor, G., Weaver, C., Daoud, F., Ladenson, J.H., Scott, M.G. Washington University case conference: CA 125 concentrations in malignant and nonmalignant diseases. Clin Chem 1991, 37, 1968–1974.
Soper, J.T., Hunter, V.J., Daly, L., Tannar, M., Creasmen, W.T., Bast, R.C. Preoperative serum tumor-associated antigen levels in women with pelvic masses. Obstet Gynecol 1990, 75, 249–54.
Moncayo, R., Moncayo, H. Serum levels of CA 125 are elevated in patients with active systemic lupus erythematosus. Obstet Gynecol 1991, 77, 932–934.
Nouwen, E.J., Pollet, D.E., Eerdekens, M.W., Hendrix, P.G., Briers, T.W., De Broe, M.E. Immunohistochemical localization of placental alkaline phosphatase, carcinoembryonic antigen and cancer antigen 125 in normal and neoplastic human lung. Cancer Res 1986, 46, 866–876.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yucel, A.E., Çalguneri, M. & Ruacan, Ş. False positive pleural biopsy and high CA125 levels in serum and pleural effusion in systemic lupus erythematosus. Clin Rheumatol 15, 197–199 (1996). https://doi.org/10.1007/BF02230341
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02230341