Clinical Rheumatology

, Volume 15, Issue 2, pp 148–153 | Cite as

Predictive value of nailfold capillaroscopy in the diagnosis of connective tissue diseases

  • D. Blockmans
  • G. Beyens
  • R. Verhaeghe
Originals

Summary

We revised the clinical files of 326 patients who underwent nailfold capillaroscopy. These patients could be subdivided into 4 groups : I : patients with clinical suspicion of connective tissue disease, II : patients with isolated Raynaud's phenomenon, III : patients with existing connective tissue disease, IV : patients with acrocyanosis, chronic pernio or related disorders. The presence of megacapillaries was noted. The sensitivity of their presence for the various categories of connective tissue disease was as follows : systemic sclerosis (n=11) : 100 %, CREST (n=15) : 73 %, MCTD (n=9) : 56 %, dermatomyositis (n=7) : 86 %. Nineteen patients with megacapillaries had no final diagnosis of connective tissue disease (specificity 93.3 %). The positive predictive value of the presence of megacapillaries for a scleroderma spectrum disorder (SSD) was 63.5 % and the negative predictive value of a normal capillaroscopy 96.7 %. We conclude that nailfold capillaroscopy can be advised to rule out SSD's.

Key words

Capillaroscopy Scleroderma Megacapillaries 

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Copyright information

© Clinical Rheumatology 1996

Authors and Affiliations

  • D. Blockmans
    • 1
  • G. Beyens
    • 2
  • R. Verhaeghe
    • 2
  1. 1.From the Department of General Internal MedicineUZ GasthuisbergLeuvenBelgium
  2. 2.Department of Vascular DisordersUZ GasthuisbergLeuvenBelgium

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