The Italian Journal of Neurological Sciences

, Volume 13, Issue 9, pp 729–733 | Cite as

EEG changes induced by carbamazepine therapy at rest and during mental processes

  • Marciani M. G. 
  • Gigli G. L. 
  • Maschio M. C. E. 
  • Stefani N. 
  • Stefanini F. 
  • Bernardi G. 
Original Articles

Abstract

The effects of carbamazepine (CBZ) on EEG backgrouund activity have been studied, at rest and during mental processes, in 18 epileptic patients suffering from focal epilepsy and starting antiepileptic treatment for the first time. The EEGs were recorded before and after CBZ therapy, at rest with eyes closed (EC), during blocking reaction (BR), fixation (FIX) and mental arithmetic (MA) tasks, and then evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated by spectral analysis. All data underwent statistical evaluation utilizing the ANOVA and correlation coefficient. The following parameters were evaluated: mean absolute and relative power and mean frequency. The results have shown that CBZ induced a significant increase of slow activity at rest with EC, which was represented by delta potentials, and was correlated with CBZ plasma levels, In evaluating the different cortical activation patterns, a decrease of the alpha reactivity was noted during BR and FIX, while a significant increase of beta activity was observed during the performance of all tasks. The rwelationship between the increased beta power, possibly reflecting an increase of cognitive activity for processing information, and the lack of a significant decrease of alpha activity are discussed.

Key Words

Carbamazepine computerized EEG mental processes focal epilepsy 

Sommario

Gli effetti della carbamazepina (CBZ) sull'attivià di fondo EEG sia a riposo che durante differenti prove di attivazione corticale sono stati studiati su 18 pazienti con epilessia focale che dovevano iniziare per la prima volta n trattamento antiepilettico. L'attività EEG è stata registrata in condizione di riposo ad occhi chiusi (EC), durante reazione d'arresto (BR), fissazione di immagini (FIX) e calcolo mentale (MA). L'analisi quantitativa EEG mediante la Fast Fourier Transform ha fornito valori di potenza assoluta e relativa media per ciascun elettrodo e banda di frequenza nelle differenti prove di attivazione prima e dopo trattamento con CBZ. I dati spettrali sono stati sottoposti ad analisi statistica che includeva l'analisi di varianza ed il coefficiente di corrlazione. I risultati ottenuti hanno mostrato che la CBZ nella situazione di riposo ad occhi chiusi determina un aumento significativo dell' attività delta che è correlato con i livelli plasmatici del foarmaco. Per quanto concerne gli effetti indotti dalle varie prove di attivazione, sempre confrontate con la situazione di riposo ad EC, è stata osservata durante BR e FIX una riduzione della reattività dell'alfa ed un aumento significativo dell'attività beta. Viene pertanto discussa la possibile correlazione tra l'incremento dell'attività beta, che verosimilmente riflette un potenziamento dell'attività cognitiva, e la diminuita reattività dell'alfa.

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Copyright information

© Masson Italia Periodici S.r.l. 1992

Authors and Affiliations

  • Marciani M. G. 
    • 1
  • Gigli G. L. 
    • 1
  • Maschio M. C. E. 
    • 1
  • Stefani N. 
    • 1
  • Stefanini F. 
    • 1
  • Bernardi G. 
    • 1
  1. 1.Clinica Neurologica Dipartimento di Sanità Pubblica, II Università di Roma Tor VergataRoma

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