Journal of Neuro-Oncology

, Volume 3, Issue 2, pp 105–111 | Cite as

Histologic and non-histologic factors correlated with survival time in supratentorial astrocytic tumors

  • F. Cohadon
  • N. Aouad
  • A. Rougier
  • C. Vital
  • J. Rivel
  • J. F. Dartigues


One hundred and ninety-two cases of supratentorial astrocytic tumors are classified in 4 groups according to the presence or absence in the pathological material of simple morphological criteria: abnormal cellular density, nuclear pleomorphism, neovascularization, necrosis. Each one of these criteria is strongly correlated with prognosis. Nevertheless only a simple classification in low and high grade lesions has a definite predictive value.

A multivariate analysis utilizing Cox's hazard function confronts these histological findings with a number of clinical and etiological possible factors of prognosis. Age and performance status at the time of diagnosis are the best predictors of survival time. The clinical use of a predictive model derived from Cox's function analysis is discussed.

Key words

astrocytomas histologic grading prognosis factors 


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Copyright information

© Martinus Nijhoff Publishers 1985

Authors and Affiliations

  • F. Cohadon
    • 1
  • N. Aouad
    • 1
  • A. Rougier
    • 1
  • C. Vital
    • 2
  • J. Rivel
    • 2
  • J. F. Dartigues
    • 3
  1. 1.Hôpital PellegrinService de Neurochirurgie ABordeaux CedexFrance
  2. 2.Hôpital PellegrinLaboratoire de NeuropathologieBordeaux CedexFrance
  3. 3.Hôpital PellegrinDepartement de StatistiquesBordeaux CedexFrance

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