Skip to main content
SpringerLink
Log in

Some aspects of the teratogenicity of veterinary drugs

  • Toxicology and Analysis
  • Published:
Veterinary Research Communications Aims and scope Submit manuscript

Abstract

The possible teratogenic effect of drugs used in veterinary medicine is important for two main reasons: safety for the target animals and residue risks for the consumers of animal products.

The general laws of chemical teratogenesis are: specific sensitivity, smallness of the teratogenic dose, existence of a sensitive period, and single dose effect. They are illustrated by different examples in domestic animals. In most cases (retinol, griseofulvin), the teratogenic doses are obviously higher than the therapeutic ones; on the contrary, in some circumstances (parbendazole, cambendazole), the safety margin is relativley low and requires strict observance of the recommended dosage.

It is pointed out that metabolism is a determining factor of teratogenesis and is related to drug residue toxicity. Yet, it is experimentally possible to distinguish inactive metabolites and teratogenic metabolites that may be present in meat and milk. Consequently, a more appropriate evaluation of risks is possible, compared to the classical method that uses total radioactivity levels. These nitions are illustrated by numerous examples of anthelmintics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Becker, W., 1976. Die Bewertung von Rückständen nach Anwendung von Panacur. Berl. Münch. Tierärztl. Wschr., 89: 453–456.

    Google Scholar 

  • Bell, J.P. and Tomlinson, R.V., 1976. Metabolites of a new anthelmintic agent, Oxfendazole. Fed. Proc., 35: 487.

    Google Scholar 

  • Binns, W., Shupe, J.L., Keeler, R.F. and James, L.F., 1965. Chronologic evaluation of teratogenicity in sheep fedVeratrum californicum. J.A.V.M.A., 147: 839–842.

    Google Scholar 

  • Delatour, P. and Richard, Y., 1976. Propriétés embryotoxiques et antimitotiques en série benzimidazole. Thérapie, 31: 505–515.

    Google Scholar 

  • Delatour, P., Lorgue, G., Courtot, D. et Lapras, M., 1975. Embryotoxicité expérimentale du Cambendazole chez le mouton. Bull. Soc. Sci. Vet. & Med. Comp. de Lyon, 77: 197–203.

    Google Scholar 

  • Delatour, P., Lorgue, G., Courtot, D. et Lapras, M., 1976. Tolérance embryonnaire de l'Oxibendazole chez le Rat et le Mouton. Rec. Med. Vet., 152: 467–470.

    Google Scholar 

  • Delatour, P., Debroye, J., Lorgue, G. et Courtot, D., 1977. Embryotoxicité expérimentale de l'oxfendazole chez le Rat et le Mouton. Rec. med. Vet., 153: 639–645.

    Google Scholar 

  • Di Cuollo, C.J., Miller, J.A., Mendelson, W.L. and Pagano, J.F., 1974. Metabolic and tissue residue studies on Parbendazole in sheep. J. Agric. Food Chem., 22: 948–953.

    Article  PubMed  Google Scholar 

  • Douch, P.G.C., 1974. The metabolism of some thioureidobenzene fungicides in mice and sheep. Xenobiotica, 4: 457–475.

    PubMed  Google Scholar 

  • Grannec, C., 1980. Albendazole: Embryotoxicité de relais (Comparaison avec l'embryotoxicité de dix métabolites). Thèse Doct. Vet. Lyon.

  • Gyurik, R.J., Chow, A.W., Zaber, B., Brunner, E.M., Miller, J.A., Villani, A.J., Petka, L.A. and Parish, R.C., 1981. Metabolism of Albendazole in cattle, sheep, rats and mice. Drug Met. Disp., 9: 503.

    Google Scholar 

  • Marriner, S.E. and Bogan, J.A., 1980. Pharmacokinetics of albendazole in sheep. Am. J. Vet. Res., 41: 1126–1129.

    PubMed  Google Scholar 

  • Martin, D., 1980. Albendazole: Etude embryotoxique de dix métabolites (Comparaison avec l'embryotoxicité de relais). Thèse Doct. Vet. Lyon.

  • Mayo, B.C., Brodie, R.R., Chasseaud, L.F. and Hawkins, D.R., 1978. Biotransformation of methyl 5-cyclopropylcarbonyl-2-benzimidazolecarbamate (Ciclobendazole) in rats and dogs. Drug Met. Disp., 6: 518–527.

    Google Scholar 

  • Meuldermans, W.E.G., Hurkmans, R.M.A., Lauwers, W.F.J. and Heykans, J.J.P., 1976. The in vitro metabolism of mebendazole by pig, rat and dog liver fractions. Europ. J. Drug Met. Pharamc., 1: 35–40.

    Google Scholar 

  • Middleton, H.D., Plant, J.W., Walker, C.E., Dixon, R.T. and Johnson, D.R., 1974. The effect of Parbendazole on reproduction in sheep and other animals. III. Teratological study in ewes in Australia. Cornell Vet., 64: suppl.no. 4, 56–58.

    PubMed  Google Scholar 

  • Shone, D.K., Philip, J.R. and Fricker, J.M., 1974. The effects of Parbendazole on reproduction in sheep and other animals. IV. Teratological study in ewes in the Republic of South Africa. Cornell Vet., 64: suppl.no. 4, 69–76.

    PubMed  Google Scholar 

  • Szabo, T.K., Miller, C.R. and Scott, G.C., 1974. The effects of Parbendazole on reproduction in sheep and other animals. II. Teratological study in ewes in the United States. Cornell Vet., 64: suppl.no. 4, 41–55.

    PubMed  Google Scholar 

  • Theodorides, V.J., Di Cuollo, C.J., Nawalinski, T., Miller, C.R., Murphy, J.R., Freeman, J.F., Killeen, J.C. and Rapp, W.R., 1977. Toxicologic and teratologic studies of oxibendazole in ruminants and laboratory animals. Am. J. Vet. Res., 38: 809–814.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biochem. Dept., Ecole Nat. Vet. de Lyon, 69260, Charbonnières, France

    P. Delatour

Authors
  1. P. Delatour
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Delatour, P. Some aspects of the teratogenicity of veterinary drugs. Vet Res Commun 7, 125–131 (1983). https://doi.org/10.1007/BF02228606

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02228606

Keywords

Search

Navigation