Pharmaceutical Chemistry Journal

, Volume 29, Issue 2, pp 124–126 | Cite as

Synthesis, anti-inflammatory and analgesic activity of pyrido[2,1-b]quinazoline derivatives

  • A. I. Mikhalev
  • M. E. Kon'shin
  • L. A. Ovodenko
  • A. S. Zaks
Search for New Drugs

Abstract

Derivatives of pyrido[2,1-b]quinazoline were synthesized by reacting 2-chloronicotinic acid, its nitrile and amides with anthranilic acid or 2-aminotriphenylcarbinol. The anti-inflammatory and analgesic activity of the compounds was studied.

Keywords

Organic Chemistry Amide Nitrile Analgesic Activity Quinazoline 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. Horvath, J. Hermez, and Z. Messzares, Bulgarian Pat. No. 184058(1987).Google Scholar
  2. 2.
    US Pat. No. 4033961 (1978), C. F. Schwender and B. R. Sundy.Google Scholar
  3. 3.
    A. I. Mikhalev, M. E. Kon'shin, O. V. Yanborisova, et al.,Khim. Farm. Th.,25(10), 37 - 38 (1991).Google Scholar
  4. 4.
    A. I. Mikhalev, V. K. Kudryashova, M. E. Kon'shin, et al.,Khim. Farm. Zh.,9(5), 15- 18 (1975).Google Scholar
  5. 5.
    O. Seide,Justus Liebbigs Ann. Chem.,440, 311 - 315 (1924).Google Scholar
  6. 6.
    M. Shur and S. Isralstam,J. Org. Chem.,33, 3015 - 3019 (1968).CrossRefGoogle Scholar
  7. 7.
    V. B. Prozorovskii and M. P. Prozorovskaya,Farmakol. Toksikol., No. 6, 733 - 735 (1980).Google Scholar
  8. 8.
    J. G. Otternes, E. H. Wiseman, and D. J. Gans,Agents and Actions,9(2), 177 - 183 (1979).CrossRefPubMedGoogle Scholar
  9. 9.
    C. A. Winter, E. A. Richtey, and G. W. Miss,Proc. Soc. Exp. Biol. (N. Y.),111, 544 - 547 (1962).Google Scholar
  10. 10.
    M. L. Belen'kii, Elements of Quantitative Assay of the Phamacological Effect [in Russian], 2nd ed., Leningrad (1963).Google Scholar
  11. 11.
    K. Koster, M. Andersen, and E. Diber,Fed. Proc.,18, 412 - 415 (1959).Google Scholar
  12. 12.
    N. B. Eddy and D. J. Lembach,J. Pharmacol. Exp. Ther., No. 3, 385 - 393 (1953).Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • A. I. Mikhalev
    • 1
    • 2
  • M. E. Kon'shin
    • 1
    • 2
  • L. A. Ovodenko
    • 1
    • 2
  • A. S. Zaks
    • 1
    • 2
  1. 1.Perm Pharmaceutical InstitutePermRussia
  2. 2.Perm Medical InstitutePermRussia

Personalised recommendations