Pharmaceutical Chemistry Journal

, Volume 29, Issue 2, pp 106–110 | Cite as

Acetals of lactams and amides of acids. Communication 78. Synthesis and biological activity of 7,8-polymethylenepurine derivatives

  • D. B. Nilov
  • A. V. Kadushkin
  • I. F. Kerbnikova
  • I. S. Nikolaeva
  • V. V. Peters
  • T. A. Gus'kova
  • R. A. Dubinskii
  • V. G. Granik
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Abstract

The condensation of diethylacetal of dimethylformamide with 4-amino-5-ethoxycarbonyl-1,2-polymethyleneimidazoles yielded derivatives of 7,8-polymethylenehypoxanthines that are precursors of 6-amino- and 6-alkylmercapto-7,8-polymethylenepurines and 1-substituted-7,8-polymethylenehypoxanthines. On the basis of the latter, 1,2-trimethylene-4,5,7,8-tetrahydro-6H-imidazo[4.5-e][1.4]diazepine-5,8-dione was obtained. The example of 6-substituted purines was used to study the antiviral activity, and 1-substituted purines were used to study the antihypertensive activity.

Keywords

Acetal Organic Chemistry Amide Biological Activity Purine 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • D. B. Nilov
    • 1
  • A. V. Kadushkin
    • 1
  • I. F. Kerbnikova
    • 1
  • I. S. Nikolaeva
    • 1
  • V. V. Peters
    • 1
  • T. A. Gus'kova
    • 1
  • R. A. Dubinskii
    • 1
  • V. G. Granik
    • 1
  1. 1.Chemical Drug Center - All-Russian Research Institute of Pharmaceutical ChemistryMoscowRussia

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