Acetals of lactams and amides of acids. Communication 78. Synthesis and biological activity of 7,8-polymethylenepurine derivatives
The condensation of diethylacetal of dimethylformamide with 4-amino-5-ethoxycarbonyl-1,2-polymethyleneimidazoles yielded derivatives of 7,8-polymethylenehypoxanthines that are precursors of 6-amino- and 6-alkylmercapto-7,8-polymethylenepurines and 1-substituted-7,8-polymethylenehypoxanthines. On the basis of the latter, 1,2-trimethylene-4,5,7,8-tetrahydro-6H-imidazo[4.5-e][1.4]diazepine-5,8-dione was obtained. The example of 6-substituted purines was used to study the antiviral activity, and 1-substituted purines were used to study the antihypertensive activity.
KeywordsAcetal Organic Chemistry Amide Biological Activity Purine
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