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Synthesis of 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine from alkylglyceryl ethers of Commander Island squid liver and its biological activity

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Abstract

The synthesis of 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine from 1-O-alkyl-sn-glycerin isolated from the liver of Commandor Island squid is described. It was found that 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine effectively inhibits the proliferation of K 562 human leukemic cells and P 815 mouse mastocytoma cells in the range of concentrations 10–100 and 50–100 ΜM, respectively.

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Authors and Affiliations

  1. Scientific and Production Firm “Biolipid”, Moscow, Russia

    V. I. Kulikov, G. I. Muzya & S. M. Orlov

  2. Institute of Sea Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia

    A. A. Popkov & E. V. Berdyshev

Authors
  1. V. I. Kulikov
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  2. G. I. Muzya
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  3. S. M. Orlov
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  4. A. A. Popkov
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  5. E. V. Berdyshev
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Kulikov, V.I., Muzya, G.I., Orlov, S.M. et al. Synthesis of 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine from alkylglyceryl ethers of Commander Island squid liver and its biological activity. Pharm Chem J 29, 93–95 (1995). https://doi.org/10.1007/BF02226517

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  • DOI: https://doi.org/10.1007/BF02226517

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