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Urgent problems in the search for and creation of β-adrenergic blocking agents

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Abstract

The results are presented of a search for hybrid Β-adrenergic blocking agents (combining Β-adrenergic blocking activity with α-adrenergic blocking, vasodilating properties, and also the ability to inhibit the angiotensin-converting enzyme) and Β-adrenergic blocking agents with a prolonged effect among the derivatives of 5-phenoxymethyl-1,2,4-oxadiazole and 4-(2-hydroxy-3-alkylaminopropoxy)indole. One of the studied substances (proxodolol) was introduced into medical practice as a highly efficacious antihypertensive. antianginal, and antiglaucoma drug.

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Authors and Affiliations

  1. Chemical Drug Center - All-Russian Research Institute of Pharmaceutical Chemistry, Moscow, Russia

    S. V. Yuzhakov

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  1. S. V. Yuzhakov
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Yuzhakov, S.V. Urgent problems in the search for and creation of β-adrenergic blocking agents. Pharm Chem J 29, 75–77 (1995). https://doi.org/10.1007/BF02226512

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  • DOI: https://doi.org/10.1007/BF02226512

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