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The histamine-diamine oxidase system and mucosal proliferation under the influence of aminoguanidine and seventy percent resection of the rat small intestine

  • Histamine in Cell Proliferation, Cancer and Clinical Studies
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Abstract

We have suggested previously that the histamine-diamine oxidase system is involved in cell proliferation. Therefore, the diamine oxidase activity and the histamine content were studied during mucosal proliferation induced by 70% resection of the small intestine of the rat with and without aminoguanidine (AG), a specific inhibitor of diamine oxidase (DAO). The DAO activity underwent a marked alteration during the period of mucosal proliferation, probably as an expression of an antiproliferative regulation mechanism. The histamine content decreased in the proliferating mucosa. No influence of AG on mucosal proliferation could be found, which might be due to a compensatory activity of the interconversion pathway.

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Authors and Affiliations

  1. II. Department of Surgery of the University of Cologne, Ostmerheimer-Strasse 200, D-5000, Köln 91, FRG

    R. Mennigen, T. Bieganski, A. Elbers & J. Kusche

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  1. R. Mennigen
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  2. T. Bieganski
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  3. A. Elbers
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  4. J. Kusche
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Mennigen, R., Bieganski, T., Elbers, A. et al. The histamine-diamine oxidase system and mucosal proliferation under the influence of aminoguanidine and seventy percent resection of the rat small intestine. Agents and Actions 27, 221–223 (1989). https://doi.org/10.1007/BF02222245

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  • DOI: https://doi.org/10.1007/BF02222245

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