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Agents and Actions

, Volume 27, Issue 1–2, pp 212–214 | Cite as

Food-induced histaminosis under diamine oxidase (DAO) blockade in pigs: Further evidence of the key role of elevated plasma histamine levels as demonstrated by successful prophylaxis with antihistamines

  • J. Sattler
  • W. Lorenz
  • K. Kubo
  • A. Schmal
  • S. Sauer
  • L. Lüben
Histamine in Cell Proliferation, Cancer and Clinical Studies

Abstract

Using a recently established porcine model, it was clearly shown that oral histamine administration is extremely dangerous in the presence of diamine oxidase (DAO) blockade. Due to the severity of the symptoms (20% death) and the clinical relevance, further interest has been focussed on strategies to prevent or alleviate food induced histaminosis. In a randomized controlled trial, 10 pigs under DAO blockade were challenged with oral histamine (60 mg). Half of these animals received a prophylactic premedication with a combination of H1- and H2-receptor antagonists. As expected, all animals developed a massive increase in plasma histamine levels, with significantly higher values in the control group (median: 123 ng/ml) compared to the antihistamine group (median: 32 ng/ml). In contrast, clinical symptoms were only observed in the control group. The maximum fall in mean arterial pressure (hypotension) was 60 mmHg (median for control group) but only 15 mmHg (median) under antihistamine pretreatment. These results firstly provide further evidence for the causal role of histamine in the new disease concept and secondly enable us to investigate appropriate therapeutic measures for patients at risk.

Keywords

Histamine Arterial Pressure Clinical Relevance Diamine Causal Role 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • J. Sattler
    • 1
  • W. Lorenz
    • 1
  • K. Kubo
    • 1
  • A. Schmal
    • 1
  • S. Sauer
    • 1
  • L. Lüben
    • 1
  1. 1.Institute for Theoretical SurgeryKlinikum der Philipps Universität MarburgMarburgFRG

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