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Serum levels of neutrophil and eosinophil chemotactic activities in mastocytosis

  • Histamine in Cell Proliferation, Cancer and Clinical Studies
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Abstract

Neutrophil and eosinophil chemotactic activities (NCA and ECA) were measured in serum from twenty-two patients with urticaria pigmentosa or systemic mastocytosis. NCA was also measured after heating serum to 56°C (heat-stable NCA). Although these factors were increased in about half of the patients there was no correlation with histamine release as estimated by the excretion of the main histamine metabolite methylimidazoleacetic acid (MelmAA) in urine. A significant increase in heat-stable NCA, however, was found in patients with pruritus and abnormal high values of MelmAA. It is concluded that only heat-stable NCA is a specific mast cell mediator, but that the heat-labile NCA and ECA are dependent on mast cells for their production by a different cell, tentatively identified as the macrophage.

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Authors and Affiliations

  1. Department of Clinical Physiology, University Hospital, S-581 85, Linköping, Sweden

    G. Granerus, L. Håkansson, G. Roupe & P. Venge

  2. Dermatology, Sahlgren's Hospital, Göteborg, Sweden

    G. Granerus, L. Håkansson, G. Roupe & P. Venge

  3. Clinical Chemistry, Academic Hospital, Uppsala, Sweden

    G. Granerus, L. Håkansson, G. Roupe & P. Venge

Authors
  1. G. Granerus
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  2. L. Håkansson
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  3. G. Roupe
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  4. P. Venge
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Granerus, G., Håkansson, L., Roupe, G. et al. Serum levels of neutrophil and eosinophil chemotactic activities in mastocytosis. Agents and Actions 27, 208–211 (1989). https://doi.org/10.1007/BF02222241

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  • DOI: https://doi.org/10.1007/BF02222241

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