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Role of thromboxane A2, leukotriene C4 and histamine in the antigen-induced vasoconstriction in perfused, sensitized guinea-pig kidney

  • Histamine and the Cardiovascular and Renal Systems
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Abstract

The existence of a role for TXA2, histamine, and possibly LTC4 in the antigen-induced renal vasoconstriction in isolated, perfused kidney of sensitized guinea-pigs is demonstrated.

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References

  1. E. S. K. Assem, N. A. Abdullah and N. S. Ghanem,Renal histamine: Release by immune stimuli. Agents and Actions19, 141–149 (1986).

    PubMed  Google Scholar 

  2. E. S. K. Assem, N. A. Abdullah and A. G. A. Cowie,Kidney Mast cells, IgE and release of inflammatory mediators capable of altering renal haemodynamics. Int. Archs. Allergy. appl. Immun.84, 212–216 (1987).

    Google Scholar 

  3. E. S. K. Assem and N. A. Abdullah,Release of Thromboxane B 2 and Leukotriene C 4 and reduction in renal perfusion in experimental anaphylactic reaction of isolated guineapig kidney. Int. Archs. Allergy appl. Immun.82, 212–214 (1987).

    Google Scholar 

  4. E. S. K. Assem and N. A. Abdullah,Experimental renal anaphylaxis: release of histamine and study of its effect on renal perfusion. Agents and Actions20, 295–298 (1987).

    PubMed  Google Scholar 

  5. N. A. Abdullah, E. S. K. Assem and B. Damerau,Anaphylatoxin-induced release of histamine from in vitro perfused guina-pig kidney. Agents and Actions23, 181–184 (1988).

    PubMed  Google Scholar 

  6. E. Pirotzky, G. Pintos-Morell, C. Burtin, J. Boudet, J. Bidault and J. Benveniste,Renal anaphylaxis I. Antigeninitiated responses from isolated perfused rat kidney. Kidney International32, 233–237 (1987).

    PubMed  Google Scholar 

  7. C. R. Pace-Asciak and A. Rosenthal,Opposition of the vasopressin-induced vasoconstriction in the isolated perfused rat kidney by some prostaglandins. Prostaglandins22, 567–574 (1981).

    PubMed  Google Scholar 

  8. E. K. Jackson, H. T. Heidemann, R. A. Branch and J. F. Gerkens,Low dose intrarenal infusions of PGE 2,PGI 2 and 6-keto PGE 1 vasodilate the in vivo rat kidney. Circ. Res.51, 67–72, 1982.

    PubMed  Google Scholar 

  9. E. Pirotzky, J. Bidault, C. Burtin, M. C. Gaubler and J. Benveniste,Release of platelet-activation factor, slow-reacting substance, and vasoactive amines from isolated rat kidneys. Kidney International25, 404–410 (1984).

    PubMed  Google Scholar 

  10. J. Benveniste, C. Boullet, C. Brink and C. Labat,The actions of PAF-acether (platelet-activating factor) on guinea-pig isolated heart preparations. Br. J. Pharmac.80, 81–83 (1983).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    N. A. Abdullah &  E. S. K. Assem

  2. University College Hospital, WC1E 6BT, London, UK

    N. A. Abdullah &  E. S. K. Assem

Authors
  1. N. A. Abdullah
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  2. E. S. K. Assem
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Abdullah, N.A., Assem, E.S.K. Role of thromboxane A2, leukotriene C4 and histamine in the antigen-induced vasoconstriction in perfused, sensitized guinea-pig kidney. Agents and Actions 27, 150–153 (1989). https://doi.org/10.1007/BF02222224

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  • DOI: https://doi.org/10.1007/BF02222224

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