Agents and Actions

, Volume 27, Issue 1–2, pp 138–141 | Cite as

The cardiac and renal effects of the complement fragment C5a des Arg are partly mediated by the release of histamine and arachidonic acid metabolites

  • N. S. Ghanem
  • N. A. Abdullah
  • E. S. K. Assem
Histamine and the Cardiovascular and Renal Systems


This report suggests that the release of various inflammatory mediators such as histamine, LTC4, D4 and E4, and TXA2 measured as the stable metabolite TXB2 are partly responsible for the various cardiac and renal effects of the complement fragment C5a des Arg anaphylatoxin, in addition to its direct vasoconstrictor activity.


Histamine Arachidonic Acid Inflammatory Mediator Acid Metabolite Renal Effect 


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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • N. S. Ghanem
    • 1
  • N. A. Abdullah
    • 1
  • E. S. K. Assem
    • 1
  1. 1.Department of PharmacologyUniversity College LondonLondonUK

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