Agents and Actions

, Volume 27, Issue 1–2, pp 62–64 | Cite as

Active sensitization does not increase the responsivity of rat peritoneal mast cells to diverse chemical stimuli

  • P. T. Peachell
  • F. L. Pearce
Histamine Release from Murine Serosal Mast Cells and Human Basophils


Peritoneal mast cells from specific pathogen-free rats that had been sensitized to the nematodeNippostrongylus brasiliensis released histamine in a dose-dependent fashion on challenge with antigen, anti-rat IgE, anti-rat IgG and concanavalin A. Cells from non-sensitized animals showed weak or insignificant responses to these agents. However, the two preparations did not obviously differ in their reactivity to a range of pharmacological agents including ATP, dextran, polyamines and calcium ionophores. Both populations were refractory to cholinergic stimulation. These results show that active sensitization does notper se lead to a global increase in mast cell reactivity or releasability.


Mast Cell Histamine Dextran Cell Reactivity Concanavalin 
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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • P. T. Peachell
    • 1
  • F. L. Pearce
    • 1
  1. 1.Department of ChemistryUniversity College LondonLondonUK

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