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Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils

  • Histamine Release from Murine Serosal Mast Cells and Human Basophils
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Abstract

Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Health Sciences, S-581 85, Linköping, Sweden

    R. G. G. Andersson, M. Bartonek, E. Lindström, I. M. Lindström & J. B. C. Toll

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  1. R. G. G. Andersson
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  2. M. Bartonek
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  3. E. Lindström
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  4. I. M. Lindström
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  5. J. B. C. Toll
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Additional information

This work was supported by grants from the Swedish Medical Research Council (04X-4498) and the 80 Years Foundation of King Gustaf V.

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Andersson, R.G.G., Bartonek, M., Lindström, E. et al. Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils. Agents and Actions 27, 25–28 (1989). https://doi.org/10.1007/BF02222188

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  • DOI: https://doi.org/10.1007/BF02222188

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