Abstract
Upon parturition, dams were fed high fat or high carbohydrate diets to which 1, 10, and 30 ppm of Aroclor 1254 were added to study the effect of diet on fat and PCB accumulation in nursing pups.
The percentage of body fat in the carcasses of 0, 8, and 16 day old pups ranged from 2.2 to 18.2% and from 1.2 to 12.0% for animals suckled by dams fed high fat and high carbohydrate rations, respectively.
Accumulation of Aroclor 1254 expressed as ppm wet weight or as total PCB's per pup was similar for animals nursed by dams fed either the high fat or high carbohydrate ration, but pups from dams fed a high carbohydrate ration also had significantly less body fat. Therefore, transfer of PCBsvia the milk appears to be more a function of the amounts of PCB's consumed by the dam than the diet's ability to increase the percentage of body fat in the pups.
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References
Carnes, R. A., J. U. Doerger, and H. L. Spark: Polychlorinated biphenyls in solid waste and solid-waste-related materials. Arch. Environ. Contam. Toxicol.1, 27 (1973).
Cecil, H. C., S. J. Harris, J. Bitman, and G. F. Fries: Polychlorinated biphenylinduced decrease in liver Vitamin A in Japanese quail and rats. Bull. Environ. Contam. Toxicol.9, 179 (1973).
Chen, P. R., H. M. Mehendale, and L. Fishbein: Effect of two isomeric tetrachlorobiphenyls on rats and their hepatic enzymes. Arch. Environ. Contam. Toxicol.1, 36 (1973).
Duke, T. W., J. I. Howe, and A. J. Wilson: A polychlorinated biphenyl (Aroclor 1254) in the water, sediment, and biota of Escombia Bay, Florida. Bull. Environ. Contamin. Toxicol.5, 171 (1970).
Duncan, D. B.: Multiple range test for correlated and heteroscidastic means. Biometrics13, 164 (1957).
Holmes, T. W., J. H. Simmons, and J. O. Tatton: Chlorinated hydrocarbons in British wildlife. Nature216, 227 (1967).
Jensen, S.: Report of a new chemical hazard. New Sci.32, 612 (1966).
Jensen, S., A. G. Johnels, M. Olsson, and G. Otterlins: DDT and PCT in marine animals from Swedish waters. Nature224, 247 (1969).
Kuratsune, M., T. Yoshimura, J. Matsuzak, and A. Yamayuchi: Epidemiological study on Yusho, a poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls. Environ. Health Perspect.1, 119 (1972).
Risebrough, R. W.: Chlorinated hydrocarbons in marine ecosystems. In M. W. Miller & G. G. Berg, eds. “Chemical fallout, current research on persistent pesticides,” Charles C. Thomas, Springfield, IL pp 5–23 (1968).
Risebrough, R. W., D. Rieche, D. B. Peakall, S. G. Herman, and M. N. Kerven: Polychlorinated biphenyls in the global ecosystem. Nature220, 1098 (1968).
Savage, E. P., J. D. Tessari, J. W. Malberg, H. W. Wheeler, and J. R. Bagley: A search for polychlorinated biphenyls in human milk in rural Colorado. Bull. Environ. Contam. Toxicol.9, 222 (1973).
Schemmel, R., O. Mickelsen, and L. Fisher: Body composition and fat depot weights of rats as influenced by ration fed dams during lactation and that fed rats after weaning. J. Nutr.103, 477 (1973).
Schemmel, R., O. Mickelsen, and J. L. Gill: Dietary obesity in rats: body weight and body fat accretion in seven strains of rats. J. Nutrition100, 1041 (1970a).
Schemmel, R., O. Mickelsen, and U. Mostosky: Influence of body weight, age, diet and sex on fat depots in rats. Anat. Rec.166, 437 (1970b).
Villeneuve, D. C., D. L. Grant, W. E. S. Phillips, M. L. Clark, and D. J. Clegg: Effects of PCB administration on microsomal enzyme activity in pregnant rabbits. Bull. Environ. Contam. Toxicol.6, 120 (1971).
Vos, J. G., and J. H. Koeman: Comparative toxicological study with polychlorinated biphenyls in chicks with special reference to porphyria, edema formation, liver necrosis and tissue residues. Toxicol. Appl. Pharmacol.17, 656 (1970).
Widdowson, E. M., and R. C. McCance: Some effects of accelerating growth. I General somatic development. Proc. Roy. Soc. (Series B), London152, 188 (1960).
Yadrick, K., K. Funk, and M. E. Zabik: Dieldrin residues in bacon cooked by two methods. J. Agr. Food Chem.19, 491 (1971).
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Michigan Agricultural Experiment Station Journal Article No. 6938
Supported in part by NIH Traineeship GM01818
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Zabik, M.E., Beebe, C. & Schemmel, R. Effect of dam's diet on PCB accumulation in nursing osborne mendel pups. Arch. Environ. Contam. Toxicol. 4, 246–256 (1976). https://doi.org/10.1007/BF02221027
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DOI: https://doi.org/10.1007/BF02221027