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Role of blood flow in protection against penetration of carcinogens into normal and healing rat gastric mucosa

Digestive Diseases and Sciences volume 40, pages 2509–2515 (1995)Cite this article

Abstract

The effects of intragastric capsaicin and gastric artery ligation on the penetration of the gastric carcinogenN[methyl-3H]-N′-nitro-N-nitrosoguanidine ([3H]MNNG) to proliferative cells were studied in normal and healing rat gastric mucosa. The percentage of S-phase cells labeled with [3H]MNNG in normal corpus mucosa was higher (7.0±2.0%) after gastric artery ligation than in controls with intact blood flow (2.7±1.0%) and in animals treated with capsaicin (1.8±0.5%). Corpus mucosal blood flow was correlated with the percentage of S-phase cells labeled with [3H] MNNG in normal controls and in capsaicin-treated animals. In healing corpus mucosa and in the antrum, capsaicin or gastric artery ligation did not affect carcinogen penetration. We conclude that blood flow protects against penetration of carcinogens to proliferative cells in normal corpus mucosa but not in the antrum. Low mucosal blood flow in the corpus could be a risk factor for initiation of gastric carcinogenesis.

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Affiliations

  1. Surgical Research Laboratory, Department of Surgery, University of Bergen, Norway

    Halfdan Sørbye MD, Joergen Westby MD, Kjell Øvrebø MD, Steinar Kvinnsland PhD & Knut Svanes MD

  2. Department of Anatomy and Cell Biology, University of Bergen, Norway

    Halfdan Sørbye MD, Joergen Westby MD, Kjell Øvrebø MD, Steinar Kvinnsland PhD & Knut Svanes MD

Authors
  1. Halfdan Sørbye MD
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  2. Joergen Westby MD
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  3. Kjell Øvrebø MD
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  4. Steinar Kvinnsland PhD
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  5. Knut Svanes MD
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Additional information

Supported by grants from the Norwegian Cancer Society and Helga Semb fond. Dr Sørbye is a Research Fellow of the Norwegian Cancer Society.

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Sørbye, H., Westby, J., Øvrebø, K. et al. Role of blood flow in protection against penetration of carcinogens into normal and healing rat gastric mucosa. Digest Dis Sci 40, 2509–2515 (1995). https://doi.org/10.1007/BF02220434

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  • DOI: https://doi.org/10.1007/BF02220434

Key Words

  • gastric mucosal blood flow
  • capsaicin
  • N-methyl-N′-nitro-N-nitrosoguanidine
  • carcinogens