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Pharmaceutical Chemistry Journal

, Volume 29, Issue 1, pp 51–53 | Cite as

Reductive alkylation of the glycopeptide antibiotic eremomycin and its derivatives

  • A. Yu. Pavlov
  • T. F. Berdnikova
  • E. N. Olsuf'eva
  • G. I. Orlova
  • M. N. Preobrazhenskaya
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Abstract

The reaction of formaldehyde and benzaldehyde with the glycopeptide antibiotic eremomycin in the presence of NaBH3CN yielded a number of methyl and benzyl derivatives substituted at the amino groups. Some of the benzyl derivatives have a high antibacterial activity, but it is somewhat less than that of the parent compounds.

Keywords

Methyl Formaldehyde Organic Chemistry Antibacterial Activity Benzyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • A. Yu. Pavlov
    • 1
  • T. F. Berdnikova
    • 1
  • E. N. Olsuf'eva
    • 1
  • G. I. Orlova
    • 1
  • M. N. Preobrazhenskaya
    • 1
  1. 1.Research Institute for Searching for New AntibioticsRussian Academy of Medical SciencesMoscowRussia

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