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Reductive alkylation of the glycopeptide antibiotic eremomycin and its derivatives

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Abstract

The reaction of formaldehyde and benzaldehyde with the glycopeptide antibiotic eremomycin in the presence of NaBH3CN yielded a number of methyl and benzyl derivatives substituted at the amino groups. Some of the benzyl derivatives have a high antibacterial activity, but it is somewhat less than that of the parent compounds.

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Pavlov, A.Y., Berdnikova, T.F., Olsuf'eva, E.N. et al. Reductive alkylation of the glycopeptide antibiotic eremomycin and its derivatives. Pharm Chem J 29, 51–53 (1995). https://doi.org/10.1007/BF02219465

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  • DOI: https://doi.org/10.1007/BF02219465

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