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Mildronate: Mechanisms of action and prospects for correction of pathologic states

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References

  1. J. Bremer,Physiol. Rev.,63(9), 1420 - 1480 (1983).

    Google Scholar 

  2. J. Bremer, H. Osmundsen, and S. Numa,Fatty acid metabolism and its regulation. Elsevier, Amsterdam (1984), pp. 113 - 153.

    Google Scholar 

  3. R. G. Bing,Physiol. Rev.,45(2), 171 - 250 (1965).

    Google Scholar 

  4. L. H. Opie,Am. Heart J.,76(5), 685 - 690 (1986).

    Google Scholar 

  5. A. Waldenstroem and A. Hjalmarson,J. Mol. Cell. Cardiol.,12. Suppl. 1, 176 - 181 (1980).

    Google Scholar 

  6. J. T. Whitmer, J. A. Idell-Wenger, M. J. Rovetto, et al.,J. Biol. Chem.,253(12), 4305 - 4309 (1978).

    Google Scholar 

  7. V. A. Kurien and M. F. Oliver,Lancet,2(7455), 122 - 127 (1966).

    Google Scholar 

  8. M. F. Oliver,Circulat. 45(3), 491 - 500 (1972).

    Google Scholar 

  9. Zh. V. Shutenko, B. Z. Simkhovich, I. Ya. Kalvin'sh, et al.,Izv. Akad. Nauk Latv. SSR, No. 11, Issue 496, 117 - 119 (1988).

    Google Scholar 

  10. D. M. Turnbull, K. Bartlett, S. J. M. Younate, et al.,Biochem. Pharmacol.,33(3), 475 - 484 (1984).

    Google Scholar 

  11. P. R. Maroko, P. Libby, B. E. Sobel, et al.,Circulation,45(5), 1160 - 1168 (1972).

    Google Scholar 

  12. L. H. Opie,J. Mol. Cell. Cardiol.,1(2), 107 - 115 (1970).

    Google Scholar 

  13. L. H. Opie, in:Cardiac Metabolism, A. J. Drake-Holland and I. M. Noble (eds.), J. Wiley, New York (1983), pp. 279 - 307.

    Google Scholar 

  14. V. A. Saks, R. Ventura-Clapier, L. A. Huchua, et al.,Biochim. Biophys. Acta,803(2), 254 - 264 (1984).

    Google Scholar 

  15. D. Sodi-Palares, M. R. Testelli, et al., F. L. Fishleder,Amer. J. Cardiol.,9(2), 166 - 169 (1962).

    Google Scholar 

  16. A. M. Katz, F. C. Messinec, et al., P. B. Pinto,Circ. Res.,48(1), 1 - 16 (1981).

    Google Scholar 

  17. K., LaNoue, W. J. Nicklas, and J. R. Williamson,J. Biol. Chem.,245(1), 102 - 111 (1970).

    Google Scholar 

  18. F. E. Hull, K. A. Waugh, M. Malone, et al.,Arch. Biochem. Biophys.,149(1), 69 - 90 (1972).

    Google Scholar 

  19. J. F. Oram, S. L. Benetch, and J. R. Neely,J. Biol. Chem.,248(18), 6299 - 6304 (1973).

    Google Scholar 

  20. S. V. Pande,J. Biol. Chem.,246(10), 5381 - 5390 (1971).

    Google Scholar 

  21. P. Harris, R. J. Bing, and A. Fleckenstein,Recent advances in studies on cardiac structure and metabolism, Vol. 8, Univ. Park Press, Baltimore (1976), pp. 13 - 21.

    Google Scholar 

  22. K. H. Moore, J. F. Radloff, F. E. Hull, et al.,Amer. J. Physiol.,239(2), H257 - H265 (1980).

    Google Scholar 

  23. J. R. Neely, H. E. Morgan,Annu. Rev. Physiol. 36(3), 413 - 459 (1974).

    Google Scholar 

  24. H. Bohles, Th. Noppeney, Z. Akcetin, et al.,Curr. Ther. Res.,39(5), 429 - 435 (1986).

    Google Scholar 

  25. P. Brecher,Mol. Cell. Biochem.,57(1), 3 - 15 (1983).

    Google Scholar 

  26. J. A. Idell-Wenger, L. W. Grotyohann, and J. R. Neely,J. Biol. Chem., 23–53(9), 4310 - 4318 (1978).

    Google Scholar 

  27. J. A. Idell-Wenger, L. W. Grotyohann, and J. R. Neely,J. Mol. Cell. Cardiol.,14(7), 413 - 417 (1982).

    Google Scholar 

  28. A. J. Liedtke, S. Nellis, and J. R. Nelly,Circ. Res.,43(4), 652 - 661. (1978).

    Google Scholar 

  29. L. H. Opie,Amer. Heart J.,97(3), 375 - 383 (1979).

    Google Scholar 

  30. A. L. Shug, J. H. Thomsen, J. D. Folts, et al.,Arch. Biochem. Biophys.,19(1), 25- 33 (1987).

    Google Scholar 

  31. A. L. Shug, B. Hayers, P. J. Huth, et al.,Carnitine Biosynthesis, Metabolism and Function, Acad. Press, New York (1980), 311 - 340.

    Google Scholar 

  32. Y. Suzuki, Y. Masumura, Kobayashi., et al.Lancet.1(8446), 116 (1982).

    Google Scholar 

  33. A. L. Shug, E. Shrago, N. Bittar. et al.,Am. J Physiol.,228(3), 689 - 692 (1975).

    Google Scholar 

  34. A. Albertini and R. Ferrari,Calcium Modulators., Elsevier (1982), pp. 5 – 16.

  35. P. Avogaro, G. Bon, Bittolo, G. Gazzolato, et al.,Pharmacol. Res. Commun.,13(13), 443 - 450 (1981).

    Google Scholar 

  36. F. C. Messineo, P. B. Pinto, and A. M. Katz,Adv. Myocardiol.,3(3), 407 - 415 (1982).

    Google Scholar 

  37. A. Fleckenstein,Calcium and the Heart, Acad. Press. New York (1971), pp. 135 - 188.

    Google Scholar 

  38. A. M. Katz, F. C. Messinec, P. B. Pinto,Clin. Res.,28. 470 (1980).

    Google Scholar 

  39. P. B. Corr, D. W. Snyder, W. A. Crafford, et al.,Circ. Res.,49(2), 354 - 363 (1981).

    Google Scholar 

  40. P. B. Corr, R. W. Gross, and B. E. Sobel,Circ. Res.,55(1), 135 - 154 (1984).

    Google Scholar 

  41. E. Downar, M. J. Janse, and D. Durrer,Circulation.56(1), 217 - 224 (1977).

    Google Scholar 

  42. H. Hayashi, Y. Suzuki, Y. Masumura, et al.,Jap. Heart J.,23(6), 623 - 630 (1982).

    Google Scholar 

  43. K. Matsui, M. Nasakawa, K. Takeda, et al.,Jap. J. Pharmacol.,39(2), 263 - 270 (1985).

    Google Scholar 

  44. R. J. Adams, D. W. Cohen, S. Gupte et al.,J. Biol. Chem.,254(23), 12404 - 12410 (1979).

    Google Scholar 

  45. J. R. B. Pitts, C. A. Tate, W. B. Van Winkle, et al.,Life Sci.,23(4), 391 - 401 (1978).

    Google Scholar 

  46. L. Atkinson, G. Bergman, N. Jackson, et al.,Br. J. Pharmacol.,66(3), 444 - 450 (1979).

    Google Scholar 

  47. K. J. Blackburn, R. A. Burges, D. G. Gardiner,Br. J. Pharmacol.,66(3), 434 - 443 (1979).

    Google Scholar 

  48. H. Korb, A. Hoeft, D. H. Hunneman, et al.,Naunyn-Schmiedebergs Arch. Pharmacol.,327(1), 70 - 74 (1984).

    Google Scholar 

  49. K. Eistetter, H. P. O. Wolf,J. Med. Chem.,25(2), 109 - 113 (1982).

    Google Scholar 

  50. H. P. O. Wolf, K. Eistetter, and Ludwig D.,Diabetologia,22(6), 456 - 463 (1982).

    Google Scholar 

  51. T. N. Molodchina and Zh. V. Shutenko, in:Abstracts of the 10th Conference of Young Scientists “Synthesis and investigation of biologically active compounds” [in Russian], Riga (1988), p. 69.

  52. B. Z. Simkhovich, R. O. Vitolinya, M. I. Stivrinya, et al.,Kardiologiya,27(7), 85- 88 (1987).

    Google Scholar 

  53. B. Z. Simkhovich, D. V. Meirena, Zh. V. Shutenko, et al.,Vopr. Med. Khim.,34(5), 30 - 34 (1988).

    Google Scholar 

  54. Zh. V. Shutenko, B. Z. Simkhovich, D. V. Meirena, et al.,Izv. Akad. Nauk Latv. SSR, No. 6, Issue 479, 102 - 105 (1987).

    Google Scholar 

  55. B. Z. Simkhovich, Zh. V. Shutenkoo, D. V. Veirena, et al.,Biochem. Pharmacol.,37(2), 195 - 202 (1988).

    Google Scholar 

  56. Zh. V. Shutenko,Author's Abstract of Candidate's Thesis, Tartu (1988), p. 16.

  57. A. J. Higgins, A. B. Morville Roger, and K. J. Blackburn,Biochem. Biophys. Res. Commun.,100(1), 291 - 296 (1981).

    Google Scholar 

  58. Y. T. Kruszynska and Ah. H. A. Stanley,Biochem. Soc. Trans.,14(4), 669 - 670 (1986).

    Google Scholar 

  59. Zh. V. Shutenko, B. Z. Simkhovich, I. A. Priedena, et al.,Izv. Akad. Nauk Latv. SSR, No. 2, Issue 511, 65 - 67 (1990).

    Google Scholar 

  60. M. L. K. Markwell, L. I. Bieber, and N. E. Tolbert,Biochem. Pharmacol.,26(18), 1697 - 1702 (1977).

    Google Scholar 

  61. J. K. Reddy and S. J. Kumar,Biochemistry,85(3), 847 - 856 (1979).

    Google Scholar 

  62. B. Z. Simkhovich, R. O. Vitolinya, M. R. Romanova, et al.,Izv. Akad. Nauk Latv. SSR, No. 6, Issue 479, 106 - 110 (1987).

    Google Scholar 

  63. Zh. V. Shutenko, B. Z. Simkhovich, R. Ya. Mezhapuke, et al.,Izv. Akad. Nauk Latv. SSR, No. 11. Issue 496, 120 - 123 (1988).

    Google Scholar 

  64. Ya. L. Briede, R. A. Ozola, B. Z. Simkhovich, et al.,Critical Problems of Pharmacology and Toxicology of Neurotropic Agents [in Russian], Riga (1986), pp. 114 – 118.

  65. M. M. Veveris and A. A. Kimenis,Critical Problems of Pharmacology and Toxicology of Neurotropic Agents [in Russian], Riga (1986), pp. 118 – 122.

  66. Zh. V. Shutenko, I. A. Priedena, R. Ya. Mezhapuke, et al.,Farmakol. Toksikol. 54(2), 55 - 56 (1991).

    Google Scholar 

  67. E. Bachman and E. Weber,Pharmacol.,36(4), 238 - 248 (1988).

    Google Scholar 

  68. K. Kheidemanis, V. Veze, I Auzinya, et al.,Izv. Latv. Akad. Nauk, No. 6 (468). 97 - 100 (1986).

    Google Scholar 

  69. K. Heidemanis and I. Balcere,Kalvins Latvijas Zinatnu Akademijas vestis. No. 11 (520), 108 - 115 (1990).

    Google Scholar 

  70. Ya. B. Blyum, I. Ya. Kalvin'sh, N. E. Kucherenko, et al.,Ukr. Biokhim. Zh.,60(6), 19 - 23 (1988).

    Google Scholar 

  71. Ya. B. Blyum, E. A. Verbvikova, I. Ya. Kalvin'sh, et al.,Izv. Latv. Akad. Nauk. No. 10, 105 - 109 (1990).

    Google Scholar 

  72. Ya. B. Blyum, I. Ya. Kalvin'sh, N. I. Bratus', et al.,Izv. Latv. Akad. Nauk. No. 8, 120 - 125 (1990).

    Google Scholar 

  73. Ya. B. Blyum, I. Ya. Kalvin'sh, N. E. Kucherenko, et al.,Ukr. Biokhim. Zh.,59(5), 718 - 724 (1987).

    Google Scholar 

  74. K. S. Medvedev, Yu. D. Babenyuk, N. I. Bratus', et al., in:The Xth All-Union Symposium “Structure and functions of the cell nucleus” [in Russian], Moscow (1990). p. 104.

  75. I. Priedena, N. Sjakste, I. Kalvins, et al.,Pharmacology of novel centrally acting drugs: Abstr. of meet. of Est., Latv., and Lith. pharmacologists, Inst. Org. Synth., Riga (1991), p. 57.

    Google Scholar 

  76. I. Priedena, I. Solovyev,8 th Conf. of young scientists organic and bioogranic chemistry: Abstr., Riga (1991). pp. 174 – 175.

  77. T. Kagan, I. Priedena, N. Sjakste, et al.,Pharmacology of novel centrally and peripherally acting drugs: Abstr. of the meet. of Est., Latv., a. Lith. pharmacologists. Inst. of Org. Synth., Riga (1991), p. 35 - 36.

    Google Scholar 

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, Latvia

    Zh. V. Shutenko, D. V. Meirena, T. I. Kagan, N. I. S'yakste & I. Ya. Kalvin'sh

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Shutenko, Z.V., Meirena, D.V., Kagan, T.I. et al. Mildronate: Mechanisms of action and prospects for correction of pathologic states. Pharm Chem J 29, 309–312 (1995). https://doi.org/10.1007/BF02219376

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