Antonie van Leeuwenhoek

, Volume 37, Issue 1, pp 313–317 | Cite as

Fusidic-acid-resistant staphylococci

  • G. R. Miller


Penicillin-resistant staphylococci were examined to determine the spontaneous mutation frequency of resistance to antistaphylococcal antibiotics including fusidic acid, cephalothin and lincomycin. Fusidic-acid-resistant mutants were obtained about twenty times more frequently than cephalothin-resistant mutants and about one hundred times more frequently than lincomycin-resistant mutants. Among the fusidic-acid-resistant mutants, ninety-seven per cent were resistant to 20 μg/ml and thirty percent to 100 μg/ml of the drug. The fusidic-acid-resistant mutants had prolonged generation times not related to the level of drug resistance. Cross-resistance between fusidic acid and cephalothin and between lincomycin and erythromycin was detected. Preliminary evidence was presented indicating that fusidic-acid-resistant mutants inactivate fusidic acid to a greater extent than sensitive cells.


Drug Resistance Erythromycin Generation Time Preliminary Evidence Mutation Frequency 
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Copyright information

© Swets & Zeitlinger 1971

Authors and Affiliations

  • G. R. Miller
    • 1
  1. 1.Department of BiologyWichita State UniversityWichitaUSA

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