Antonie van Leeuwenhoek

, Volume 37, Issue 1, pp 313–317 | Cite as

Fusidic-acid-resistant staphylococci

  • G. R. Miller
Article

Abstract

Penicillin-resistant staphylococci were examined to determine the spontaneous mutation frequency of resistance to antistaphylococcal antibiotics including fusidic acid, cephalothin and lincomycin. Fusidic-acid-resistant mutants were obtained about twenty times more frequently than cephalothin-resistant mutants and about one hundred times more frequently than lincomycin-resistant mutants. Among the fusidic-acid-resistant mutants, ninety-seven per cent were resistant to 20 μg/ml and thirty percent to 100 μg/ml of the drug. The fusidic-acid-resistant mutants had prolonged generation times not related to the level of drug resistance. Cross-resistance between fusidic acid and cephalothin and between lincomycin and erythromycin was detected. Preliminary evidence was presented indicating that fusidic-acid-resistant mutants inactivate fusidic acid to a greater extent than sensitive cells.

Keywords

Drug Resistance Erythromycin Generation Time Preliminary Evidence Mutation Frequency 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barber, M. andGarrod, L. P. 1963. Antibiotic and chemotherapy, p. 209. - Williams and Wilkins Co., Baltimore.Google Scholar
  2. Campbell, A. M. 1969. Episomes, p. 66. - Harper and Row, New York.Google Scholar
  3. Demerec, M. 1945. Production ofStaphylococcus strains resistant to various concentrations of penicillin. - Proc. Nat. Acad. Sci. U.S.31: 16–24.Google Scholar
  4. Finland, M. 1965. Staphylococcal infections and antistaphylococcal antibiotics. - Med. Times, Port Wash., N. Y.93: 101–104.Google Scholar
  5. Harvey, C. I., Shi, C. J. andKnight, S. G. 1967. Fucidin, p. 404–409.In. D. Gottlieb and P. D. Shaw, (eds.), Antibiotics, Vol. I, Mechanism of action. - Springer-Verlag, New York.Google Scholar
  6. Lederberg, J. andLederberg, E. M. 1952. Replica plating and indirect selection of bacterial mutants. - J. Bacteriol.63: 399–406.PubMedGoogle Scholar

Copyright information

© Swets & Zeitlinger 1971

Authors and Affiliations

  • G. R. Miller
    • 1
  1. 1.Department of BiologyWichita State UniversityWichitaUSA

Personalised recommendations