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Synthesis of 2-dichloromethyl-2-methyl [2-14C]-1,3-dioxolane

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Abstract

The labelled compound was prepared by chlorination of [2-14C]acetone obtained from the barium salt of [1-14C]acetic acid by pyrolysis. The reaction product 1,1-dichloro [2-14C]acetone was converted to 2-dichloromethyl-2-methyl [2-14C]-1,3-dioxolane by condensation with ethylene glycol in the presence of thionyl chloride. Radiochemical yield: 62% based on [1-14C]acetic acid.

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Authors and Affiliations

  1. Central Research Institute for Chemistry, Hungarian Academy of Sciences, P. O. Box 17, H-1525, Budapest, Hungary

    I. Jablonkai & F. Dutka

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  1. I. Jablonkai
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  2. F. Dutka
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Jablonkai, I., Dutka, F. Synthesis of 2-dichloromethyl-2-methyl [2-14C]-1,3-dioxolane. Journal of Radioanalytical and Nuclear Chemistry Letters 144, 173–177 (1990). https://doi.org/10.1007/BF02218160

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  • DOI: https://doi.org/10.1007/BF02218160

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