Virchows Archiv A

, Volume 390, Issue 2, pp 229–241 | Cite as

Astrocytes of the cerebral cortex in hepatosplenic schistosomiasis mansoni and in liver cirrhosis

A morphological, quantitative and karyometric study
  • José Eymard Homem Pittella
Original Articles

Summary

A morphological, quantitative and karyometric study of astrocytes of the cerebral cortex in patients with liver cirrhosis, hepatosplenic schistosomiasis mansoni and controls is reported. Cell proliferation was commonly seen but there was no significant increase in number of astrocytes in either cirrhosis and schistosomiasis groups. A highly significant increase in astrocyte nuclear volume in cirrhosis and schistosomiasis in relation to controls was observed. The astrocyte average nuclear volume in the cirrhotics was also significantly increased in relation to the schistosomiasis group. From the present data and those reported by other investigators it may be concluded that under normal conditions the astrocyte population is continually reforming and it proliferates in liver cirrhosis and hepatosplenic schistosomiasis. It seems that the morphological, quantitative and karyometric astrocyte changes in schistosomiasis may be the result of the same factors as those previously described for liver cirrhosis and experimental portacaval shunt.

Key words

Glia cells Cell number Karyometry Cerebral cortex Schistosomiasis Liver cirrhosis 

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References

  1. Adams RD, Foley JM (1953) The neurological disorder associated with liver disease. In: Metabolic and toxic diseases of the nervous system. Proc Ass Res Nerv Ment Dis, 32, Chapter XI. Williams and Wilkins Co, Baltimore, pp 198–237Google Scholar
  2. Alajouanine T, Bertrand I, Boudin G, Pépin B (1955) Etude anatomo-clinique, biologique et chimique d'un cas de pseudo-sclérose de Westphal-Strümpell. Rev Neurol 93:701–729PubMedGoogle Scholar
  3. Barnes S, Hurst EW (1925) Hepato-lenticular degeneration. Brain 48:279–333Google Scholar
  4. Bogliolo L (1972) Liver and biliary ways (in Portugese). In: Patologia, Bogliolo (ed) Cap 21, 1st edn. Guanabara Koogan, Rio de JaneiroGoogle Scholar
  5. Bogliolo L (1976) Liver and biliary ways (in Portugese). In: Patologia, Bogliolo (ed) Cap 19, 2nd edn. Guanabara Koogan, Rio de Janeiro, p 670Google Scholar
  6. Boudin G, Barbizet J, Brion S, Nivet M, Masson S (1959) Epilepsie subintrante et grande insuffisance hépatique. Étude clinique, életrique et anatomique de six cirrhoses alcooliques ascitiques avec état de mal. Bull Mem Soc Med Hosp Paris 75:301–313Google Scholar
  7. Brown IA (1957) Liver-brain relationships. Charles C. Thomas, Springfield, IllinoisGoogle Scholar
  8. Bruton CJ, Corsellis JAN, Russell A (1970) Hereditary hyperammonaemia. Brain 93:423–434PubMedGoogle Scholar
  9. Case Records of the Massachusetts General Hospital (Case 44041) (1958) N Engl J Med 258:190–195Google Scholar
  10. Cavanagh JB, Kyu MH (1969) Colchicine-like effect on astrocytes after portacaval shunt in rats. Lancet 2:620–622PubMedGoogle Scholar
  11. Cavanagh JB, Kyu MH (1971a) Type II Alzheimer change experimentally produced in astrocytes in the rat. J Neurol Sci 12:63–75PubMedGoogle Scholar
  12. Cavanagh JB, Kyu MH (1971b) On the mechanism of type I Alzheimer abnormality in the nuclei of astrocytes. An essay in quantitative histology. J Neurol Sci 12:241–261PubMedGoogle Scholar
  13. Cavanagh JB (1972) The significance of astrocyte changes in chronic liver disease. J Pathol 107:p viiiGoogle Scholar
  14. Cavanagh JB (1974) Liver bypass and the glia. In: Plum F (ed) Brain dysfunction in metabolic disorders. Res Publ Assoc Nerv Ment Dis, Vol 53. Raven Press, New YorkGoogle Scholar
  15. Coelho MV (1959) Geographical distribution of Schistosomiasis mansoni (in Portugese) Rev Brasil Malariol D Trop 11:219–246Google Scholar
  16. Cole M, Rutherford RB, Smith FO (1972) Experimental ammonia encephalopathy in the primate. Arch Neurol 26:130–136PubMedGoogle Scholar
  17. Coutinho A, Domingues ALC (1978) Schistosomiasis mansoni (in Portugese). In: Dani R, Paula Castro L, Pérez V, Arabehety JT (eds) Gastroenterologia, Cap 69, Guanabara Koogan, Rio de JaneiroGoogle Scholar
  18. Demole V, Redalié L (1922) Syndromes extrapyramidaux apparentés a la dégénérescence hépatolenticulaire. Rev Neurol 38:1248–1269Google Scholar
  19. Documenta Geigy (1965) Scientific tables, 6th edn. JR Geigy SA, BaselGoogle Scholar
  20. Doyle D (1967) Portocaval anastomosis in rats. MD Thesis, University of EdinburghGoogle Scholar
  21. Erbslöh F (1958) Das Zentralnervensystem bei Leberkrankheiten. In: Henke F, Lubarsch O, Rössle R (eds) Handbuch der speziellen pathologischen Anatomie und Histologie, 13. Band, Nervensystem, Scholz W (ed) 2. Teil, Bandteil B. Springer, Berlin Heidelberg New York, p 1645–1698Google Scholar
  22. Faust EC, Russell PF (1964) Craig and Faust's clinical parasitology, 7th edn, Lea and Febiger, PhiladelphiaGoogle Scholar
  23. Foncin JF, Nicolaidis S (1970) Encéphalopathie porto-cave: contribution à la pathologie ultrastructurale de la glie chez l'homme. Rev Neurol 123:81–87PubMedGoogle Scholar
  24. Gibson JB (1963) Encephalopathy after portacaval shunt. Br Med J 1:1652–1655Google Scholar
  25. Greenfoeld JG, Poynton FJ, Walshe FMR (1924) On progressive lenticular degeneration (hepatolenticular degeneration). Q J Med 17:385–402Google Scholar
  26. Greenfield JG (1953) Is hepato-lenticular degeneration a clinicopathological entity? Proc R Soc Med 47:150–152Google Scholar
  27. Greenfield JG, Meyer A (1963) General pathology of the nerve cell and neuroglia. In: Greenfield's neuropathology, 2nd edn. Edward Arnold LTD, LondonGoogle Scholar
  28. Guillain G, Bertrand I, Godet-Guillain M (1954) Étude anatomique d'un cas de “Syndrome hépatolenticulaire”. Atteinte très accentuée des régions corticale et sous-corticale de l'encéphale. Rev Neurol 90:169–186PubMedGoogle Scholar
  29. Gutierrez JA, Norenberg MD (1975) Alzheimer II astrocytosis following methionine sulfoximine. Arch Neurol 32:123–126PubMedGoogle Scholar
  30. Gutierrez JA, Norenberg MD (1977) Ultrastructural study of methionine sulfoximine-induced Alzheimer type II astrocytosis. Am J Pathol 86:285–300PubMedGoogle Scholar
  31. Hagen A, Lahl R (1978) Beitrag zur atypischen Makroglia bei nichthepatogenen Erkrankungen. Zentralbl Allg Pathol 122:522–527PubMedGoogle Scholar
  32. Hommes OR, Leblond CP (1967) Mitotic division of neuroglia in the normal adult rat. J Comp Neurol 129:269–278PubMedGoogle Scholar
  33. Hösslin C von, Alzheimer A (1912) Ein Beitrag zur Klinik und pathologischen Anatomie der Westphal-Strümpellschen Pseudosklerose. Z Neurol Psychiatr 8:183–209Google Scholar
  34. Inose T (1952) Hepatocerebral degeneration, a special type. J Neuropathol Exp Neurol 11:401–408PubMedGoogle Scholar
  35. Jervis GA, Notkin J, Freiman IS, Moore J (1942) Progressive lenticular degeneration (Wilson's disease). Psychiat Quart 16:357–372Google Scholar
  36. Kalm H (1958) Auswirkungen chronischer Lebererkrankungen auf Funktion und Struktur des Gehirns. Gastroenterologia 90:259–270PubMedGoogle Scholar
  37. Kline DG, Doberneck RC, Chun BK, Rutherford RB (1966) Encephalopathy in graded portacaval shunts. Ann Surg 164:1003–1012PubMedGoogle Scholar
  38. Kline DG, Crook JN, Nance FC (1971) Eck fistula encephalopathy: long-term studies in primates. Ann Surg 173:97–103PubMedGoogle Scholar
  39. Korenke HD (1965) Über die Leukoenzephalopathie bei Lebererkrankungen. Zentralbl Allg Pathol 107:73–74Google Scholar
  40. Lahl R (1967) Zur Häufigkeit astrozytärer Gliaveränderungen (“Leberglia”) bei hepatogenen Erkrankungen, insbesondere Leberzirrhosen, und ihre Abhängigkeit vom Funktionszustand des Organs. Zentralbl Allg Pathol 110:518–545PubMedGoogle Scholar
  41. Lapham LW (1962) Cytologic and cytochemical studies of neuroglia. I. A study of the problem of amitosis in reactive protoplasmic astrocytes. Am J Pathol 41:1–21PubMedGoogle Scholar
  42. Lapham LW, Johnstone MA (1964) Cytologic and cytochemical studies of neuroglia. III. The DNA content of giant fibrous astrocytes, with implications concerning the nature of these cells. J Neuropathol Exp Neurol 23:419–430PubMedGoogle Scholar
  43. Lewis AJ (1976) Mechanisms of neurological disease, 1st edn. Little, Brown and Company, BostonGoogle Scholar
  44. Luse SA (1958) Ultrastructure of reactive and neoplastic astrocytes. Lab Invest 7:401–417PubMedGoogle Scholar
  45. Martinez A (1968) Electron microscopy in human hepatic encephalopathy. Acta Neuropathol 11:82–86PubMedGoogle Scholar
  46. Martinez-Hernandez A, Bell KP, Norenberg MD (1977) Glutamine synthetase: glial localization in brain. Science 195:1356–1358PubMedGoogle Scholar
  47. McDougal DB, Adams RD (1950) The neuropathological changes in hemochromatosis. J Neuropathol Exp Neurol 9:117–118Google Scholar
  48. Nance FC, Kline DG (1971) Eck's fistula encephalopathy in germfree dogs. Ann Surg 174:856–862PubMedGoogle Scholar
  49. Neubuerger KT (1957) The changing neuropathologic picture of chronic alcoholism. Arch Pathol 63:1–6Google Scholar
  50. Neves J, Cunha AS (1978) Schistosomiasis mansoni. In: Neves J (ed) Diagnosis and treatment of infective and parasitological diseases (in Portugese). Guanabara Koogan, Rio de JaneiroGoogle Scholar
  51. Nicolajev V (1937) Zur Frage der Beziehungen zwischen Leber und Gehirn. Virchows Arch pathol Anat 299:309–315Google Scholar
  52. Noetzel H, Oster C (1957) Über Gehirnveränderungen bei Lebererkrankungen. Beitr pathol Anat 118:325–338PubMedGoogle Scholar
  53. Norenberg MB, Lapham LW, Eastland MW, May AG (1972) Division of protoplasmic astrocytes in acute experimental hepatic encephalopathy. An electron microscopic study. Am J Pathol 67:403–411PubMedGoogle Scholar
  54. Norenberg MD, Lapham LW (1974) The astrocyte response in experimental portal-systemic encephalopathy: an electron microscopic study. J Neuropathol Exp Neurol 33:422–435PubMedGoogle Scholar
  55. Penfield W (1932) Neuroglia and microglia. The interstitial tissue of the central nervous system. In: Cowdry's special cytology, Vol 3, Chap 36, 2nd edn. Paul B Hoeber, Inc, New YorkGoogle Scholar
  56. Richter R (1948) The pallial component in hepato-lenticular degeneration. J Neuropathol Exp Neurol 7:1–18Google Scholar
  57. Rio-Hortega P del, Penfield W (1927) Cerebral cicatrix. The reaction of neuroglia and microglia to brain wounds. Bull Johns Hopkins Hosp 41:278–303Google Scholar
  58. Scherer HJ (1933) Zur Frage der Beziehungen zwischen Leber- und Gehirnveränderungen. Virchows Arch path Anat 288:333–345Google Scholar
  59. Smart I, Leblond CP (1961) Evidence for division and transformations of neuroglia cells in the mouse brain, as derived from radioautography after injection of thymidine-H3. J Comp Neurol 116:349–367Google Scholar
  60. Stadler H (1936) Histopathologische Untersuchungen zur Frage der Beziehung zwischen Leberund Gehirnveränderungen. Z Neurol Psychiatr 154:626–657Google Scholar
  61. Tarnowska-Dziduszko E, Wald I (1971) Study on glial changes in hepato-lenticular degeneration. Pol Med J 10:743–749PubMedGoogle Scholar
  62. Taylor P, Schoene WC, Reid WA, Lichtenberg F von (1979) Quantitative changes in astrocytes after portacaval shunting. In chimpanzees and in man with normal liver parenchyma. Arch Pathol Lab Med 103:82–85PubMedGoogle Scholar
  63. Victor M, Adams RD, Cole M (1965) The acquired (non-Wilsonian) type of chronic hepatocerebral degeneration. Medicine 44:345–396PubMedGoogle Scholar
  64. Waggoner RW, Malamud N (1942) Wilson's disease in the light of cerebral changes following ordinary acquired liver disorders. J Nerv Ment Dis 96:410–423Google Scholar
  65. Woerkom W van (1914) La cirrhose hépatique avec altération dans les centres nerveux évoluant chez des sujets d'âge moyen. Nouv Iconogr Salpet 7:41–51Google Scholar
  66. Worms R, Bertrand I, Godet-Guillain M, Goudal H (1959) Hémorragies digestives et système nerveux. Journées Françaises de Gastro-entérologie, Paris, octobre 1959. Arch Mal App Dig 48:1607–1611Google Scholar
  67. Worms R, Bertrand I, Godet-Guillain M, Goudal MH (1960) Le cerveau des cirrhotiques, à propos de 30 observations anatomocliniques. Bull Mem Soc Med Hop Paris 76:1153–1170PubMedGoogle Scholar
  68. Zamora AJ, Cavanagh JB, Kyu MH (1973) Ultrastructural responses of the astrocytes to portocaval anastomosis in the rat. J Neurol Sci 18:25–45PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • José Eymard Homem Pittella
    • 1
  1. 1.Department of Pathology, Faculty of MedicineFederal University of Minas GeraisBelo HorizonteBrazil

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